Rabbit anti-Human OAS2 Polyclonal Antibody | anti-OAS2 antibody

OAS2 Antibody

Cat. Num. AAA7118826

• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: OAS2; Polyclonal Antibody; OAS2 Antibody; 2'-5'-oligoadenylate synthase 2; (2-5')oligo(A) synthase 2; 2-5A synthase 2; p69 OAS / p71 OAS; p69OAS / p71OAS; anti-OAS2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: Liquid; In Phosphate Buffered Saline, 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.

• Applicable Applications for anti-OAS2 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:500-1:2000; ELISA: 1:20000
• Immunogen: Synthesized peptide derived from the N-terminal region of human OAS2.
• Immunogen Species: Human
• Conjugate: Non-conjugated
• Preparation and Storage: Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.

Western Blot (WB)

(Western Blot analysis of HeLa cells using OAS2 Polyclonal Antibody)

Product Categories/Family for anti-OAS2 antibody

Immunology

NCBI and Uniprot Product Information

• NCBI GI #: 116242687
• NCBI GeneID: 4939
• UniProt Accession #: P29728; Q6PJ33; Q86XX8; A8K9T1
• Molecular Weight: 719
• NCBI Official Full Name: 2'-5'-oligoadenylate synthase 2
• NCBI Official Synonym Full Names: 2'-5'-oligoadenylate synthetase 2, 69/71kDa
• NCBI Official Symbol: OAS2
• NCBI Protein Information: 2'-5'-oligoadenylate synthase 2; 2-5A synthase 2; p69 OAS / p71 OAS; (2'-5')oligo(A) synthetase 2
• UniProt Protein Name: 2'-5'-oligoadenylate synthase 2
• Protein Family: 2'-5'-oligoadenylate synthase
• UniProt Gene Name: OAS2
• UniProt Synonym Gene Names: (2-5')oligo(A) synthase 2; 2-5A synthase 2; p69OAS / p71OAS
• UniProt Entry Name: OAS2_HUMAN

NCBI Description

This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Uniprot Description

OAS2: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Belongs to the 2-5A synthase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.7.7.84; Transferase

Chromosomal Location of Human Ortholog: 12q24.2

Cellular Component: mitochondrion; intracellular membrane-bound organelle; membrane; endoplasmic reticulum; perinuclear region of cytoplasm; cytoplasm; nucleus; cytosol

Molecular Function: zinc ion binding; metal ion binding; double-stranded RNA binding; ATP binding; 2'-5'-oligoadenylate synthetase activity

Biological Process: cytokine and chemokine mediated signaling pathway; response to virus; RNA catabolic process; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; protein myristoylation; protein amino acid glycosylation; purine nucleotide biosynthetic process; defense response to virus