Rabbit OAS1 Polyclonal Antibody | anti-OAS1 antibody

OAS1 Rabbit Polyclonal

Cat. Num. AAA7602182

• Gene Names: OAS1; OIAS; IFI-4; OIASI; E18/E16
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: OAS1; Polyclonal Antibody; OAS1 Rabbit Polyclonal; anti-OAS1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 364

• Applicable Applications for anti-OAS1 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: 2', 5'-oligoadenylate synthetase 1, 40/46kDa
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human liver tissue slide using MBS7602182 (OAS1 Antibody) at dilution of 1:200)

Western Blot (WB)

(HeLa cells were subjected to SDS PAGE followed by western blot with MBS7602182 (OAS1 antibody) at dilution of 1:500)

NCBI and Uniprot Product Information

• NCBI GI #: 823674878
• NCBI GeneID: 4938
• Molecular Weight: 43,944 Da
• NCBI Official Full Name: OAS1, partial
• NCBI Official Synonym Full Names: 2'-5'-oligoadenylate synthetase 1
• NCBI Official Symbol: OAS1
• NCBI Official Synonym Symbols: OIAS; IFI-4; OIASI; E18/E16
• NCBI Protein Information: 2'-5'-oligoadenylate synthase 1
• UniProt Protein Name: 2'-5'-oligoadenylate synthase 1
• Protein Family: 2'-5'-oligoadenylate synthase
• UniProt Gene Name: OAS1
• UniProt Synonym Gene Names: OIAS; (2-5')oligo(A) synthase 1; 2-5A synthase 1
• UniProt Entry Name: OAS1_HUMAN

NCBI Description

This gene is induced by interferons and encodes a protein that synthesizes 2',5'-oligoadenylates (2-5As). This protein activates latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. Alternative splicing results in multiple transcript variants with different enzymatic activities. Polymorphisms in this gene have been associated with susceptibility to viral infection and diabetes mellitus, type 1. A disease-associated allele in a splice acceptor site influences the production of the p46 splice isoform. This gene is located in a cluster of related genes on chromosome 12. [provided by RefSeq, Feb 2016]

Uniprot Description

OAS1: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L. Belongs to the 2-5A synthase family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.7.7.84; Transferase

Chromosomal Location of Human Ortholog: 12q24.2

Cellular Component: cytosol

Molecular Function: 2'-5'-oligoadenylate synthetase activity; ATP binding; double-stranded RNA binding; protein binding

Biological Process: glucose homeostasis; glucose metabolic process; negative regulation of viral genome replication; response to virus

Disease: Diabetes Mellitus, Insulin-dependent