Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human testis using MBS7602177 (NXN antibody) at dilution of 1:50)
Rabbit NXN Polyclonal Antibody | anti-NXN antibody
NXN Rabbit Polyclonal
Immunogen Affinity Purified
Immunogen Affinity Purified
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human testis using MBS7602177 (NXN antibody) at dilution of 1:50)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human testis using MBS7602177 (NXN antibody) at dilution of 1:50)
Immunofluorescence (IF)
(Immunofluorescent analysis of HepG2 cells, using MBS7602177 (NXN antibody) at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red))
Immunofluorescence (IF)
(Immunofluorescent analysis of HepG2 cells, using MBS7602177 (NXN antibody) at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red))
Western Blot (WB)
(HeLa cells were subjected to SDS PAGE followed by western blot with MBS7602177 (NXN antibody) at dilution of 1:400)
Western Blot (WB)
(HeLa cells were subjected to SDS PAGE followed by western blot with MBS7602177 (NXN antibody) at dilution of 1:400)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the thioredoxin superfamily, a group of small, multifunctional redox-active proteins. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. The encoded protein acts a redox-dependent regulator of the Wnt signaling pathway and is involved in cell growth and differentiation. [provided by RefSeq, Sep 2015]
Uniprot Description
NXN: Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A). Belongs to the nucleoredoxin family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 1.8.1.8; Oxidoreductase
Chromosomal Location of Human Ortholog: 17p13.3
Cellular Component: cytosol; nucleus
Molecular Function: protein-disulfide reductase activity; thioredoxin-disulfide reductase activity
Biological Process: cell differentiation; negative regulation of protein ubiquitination; negative regulation of Wnt receptor signaling pathway; Wnt receptor signaling pathway
Research Articles on NXN
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Product Notes
The NXN nxn (Catalog #AAA7602177) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The NXN Rabbit Polyclonal reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's NXN can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP). Researchers should empirically determine the suitability of the NXN nxn for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NXN, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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