Goat NUP62 Polyclonal Antibody | anti-NUP62 antibody
Goat anti-NUP62 Antibody
Western Blot: Preliminary experiments gave an approx 30kDa band in Human Testis lysates after 0.5ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 53.3kDa according to NP_036478.2, NP_057637.2, NP_714940.1 and NP_714941.1. The 30kDa band was successfully blocked by incubation with the immunizing peptide.
NCBI and Uniprot Product Information
NCBI Description
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins and is localized to the nuclear pore central plug. This protein associates with the importin alpha/beta complex which is involved in the import of proteins containing nuclear localization signals. Multiple transcript variants of this gene encode a single protein isoform. [provided by RefSeq, Jul 2008]
Uniprot Description
NUP62: Essential component of the nuclear pore complex. The N- terminal is probably involved in nucleocytoplasmic transport. The C-terminal is probably involved in protein-protein interaction via coiled-coil formation and may function in anchorage of p62 to the pore complex. Defects in NUP62 are the cause of infantile striatonigral degeneration (SNDI); also known as infantile bilateral striatal necrosis (IBSN) or familial striatal degeneration. SNDI is a neurological disorder characterized by symmetrical degeneration of the caudate nucleus, putamen and occasionally the globus pallidus, with little involvement of the rest of the brain. The clinical features include developmental regression, choreoathetosis, dystonia, spasticity, dysphagia, failure to thrive, nystagmus, optic atrophy and mental retardation. Belongs to the nucleoporin NSP1/NUP62 family.
Protein type: Nucleoporin; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 19q13.33
Cellular Component: annulate lamellae; cytoplasm; intracellular membrane-bound organelle; nuclear envelope; nuclear membrane; nuclear pore; nucleocytoplasmic shuttling complex; pore complex; ribonucleoprotein complex; spindle pole
Molecular Function: chromatin binding; Hsp70 protein binding; Hsp90 protein binding; kinesin binding; nucleocytoplasmic transporter activity; phospholipid binding; protein binding; PTB domain binding; receptor signaling complex scaffold activity; SH2 domain binding; structural constituent of nuclear pore; thyroid hormone receptor binding; ubiquitin binding
Biological Process: cell aging; cell death; cell surface receptor linked signal transduction; hormone-mediated signaling; mitosis; mitotic nuclear envelope disassembly; mRNA export from nucleus; negative regulation of apoptosis; negative regulation of cell proliferation; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of MAP kinase activity; negative regulation of programmed cell death; negative regulation of Ras protein signal transduction; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of transcription, DNA-dependent; protein import into nucleus; protein sumoylation; regulation of protein import into nucleus; regulation of Ras protein signal transduction; regulation of signal transduction; RNA export from nucleus; RNA-mediated gene silencing; spermatogenesis; transcription, DNA-dependent; tRNA export from nucleus; viral reproduction; viral transcription
Disease: Striatonigral Degeneration, Infantile
Research Articles on NUP62
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Product Notes
The NUP62 nup62 (Catalog #AAA421074) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti-NUP62 Antibody reacts with Expected from sequence similarity: Human, Dog, Cow and may cross-react with other species as described in the data sheet. AAA Biotech's NUP62 can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA). Peptide ELISA: Antibody detection limit dilution 1: 8000. Western Blot: Preliminary experiments gave an approx 30kDa band in Human Testis lysates after 0.5ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 53.3kDa according to NP_036478.2, NP_057637.2, NP_714940.1 and NP_714941.1. The 30kDa band was successfully blocked by incubation with the immunizing peptide. Researchers should empirically determine the suitability of the NUP62 nup62 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: RKEQERSFRI TFD. It is sometimes possible for the material contained within the vial of "NUP62, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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