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NUP62 cdna clone
NUP62 cDNA Clone
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NCBI and Uniprot Product Information
NCBI Description
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins and is localized to the nuclear pore central plug. This protein associates with the importin alpha/beta complex which is involved in the import of proteins containing nuclear localization signals. Multiple transcript variants of this gene encode a single protein isoform. [provided by RefSeq, Jul 2008]
Uniprot Description
NUP62: Essential component of the nuclear pore complex. The N- terminal is probably involved in nucleocytoplasmic transport. The C-terminal is probably involved in protein-protein interaction via coiled-coil formation and may function in anchorage of p62 to the pore complex. Defects in NUP62 are the cause of infantile striatonigral degeneration (SNDI); also known as infantile bilateral striatal necrosis (IBSN) or familial striatal degeneration. SNDI is a neurological disorder characterized by symmetrical degeneration of the caudate nucleus, putamen and occasionally the globus pallidus, with little involvement of the rest of the brain. The clinical features include developmental regression, choreoathetosis, dystonia, spasticity, dysphagia, failure to thrive, nystagmus, optic atrophy and mental retardation. Belongs to the nucleoporin NSP1/NUP62 family.
Protein type: Adaptor/scaffold; Nucleoporin
Chromosomal Location of Human Ortholog: 19q13.33
Cellular Component: pore complex; spindle pole; nucleocytoplasmic shuttling complex; nuclear membrane; intracellular membrane-bound organelle; cytoplasm; nuclear envelope; nuclear pore; ribonucleoprotein complex
Molecular Function: protein binding; ubiquitin binding; receptor signaling complex scaffold activity; structural constituent of nuclear pore; PTB domain binding; SH2 domain binding; thyroid hormone receptor binding; chromatin binding; nucleocytoplasmic transporter activity
Biological Process: negative regulation of epidermal growth factor receptor signaling pathway; cell death; negative regulation of MAP kinase activity; mRNA transport; hormone-mediated signaling; viral reproduction; positive regulation of transcription, DNA-dependent; mitotic nuclear envelope disassembly; regulation of signal transduction; pathogenesis; nucleocytoplasmic transport; viral infectious cycle; glucose transport; negative regulation of cell proliferation; protein transport; cell surface receptor linked signal transduction; positive regulation of epidermal growth factor receptor signaling pathway; negative regulation of programmed cell death; negative regulation of Ras protein signal transduction; viral transcription; transmembrane transport; regulation of Ras protein signal transduction; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; cell aging; hexose transport; carbohydrate metabolic process; gene expression; mitotic cell cycle; negative regulation of apoptosis
Disease: Striatonigral Degeneration, Infantile
Research Articles on NUP62
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Product Notes
The NUP62 nup62 (Catalog #AAA1271378) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGAGCGGGT TTAATTTTGG AGGCACTGGG GCCCCTACAG GCGGGTTCAC GTTTGGCACT GCAAAGACGG CAACAACCAC ACCTGCTACA GGGTTTTCTT TCTCCACCTC TGGCACTGGA GGGTTTAATT TTGGGGCTCC CTTCCAACCA GCCACAAGTA CCCCTTCCAC CGGCCTGTTC TCACTTGCCA CCCAGACTCC GGCCACACAG ACGACAGGCT TCACTTTTGG AACAGCGACT CTTGCTTCGG GGGGAACTGG ATTTTCTTTG GGGATCGGTG CTTCAAAGCT CAACTTGAGC AACACAGCTG CCACCCCAGC CATGGCAAAC CCCAGCGGCT TTGGGCTGGG CAGCAGCAAC CTCACTAATG CCATATCGAG CACCGTCACC TCCAGCCAGG GCACAGCACC CACCGGCTTT GTGTTTGGCC CCTCCACCAC CTCTGTGGCT CCAGCTACCA CATCTGGAGG CTTCTCATTC ACTGGTGGAA GCACGGCCCA ACCCTCCGGT TTCAACATTG GCTCAGCAGG GAATTCAGCC CAGCCCACGG CACCTGCCAC GTTGCCCTTC ACTCCGGCCA CGCCAGCAGC CACCACAGCA GGTGCCACAC AGCCAGCTGC TCCCACACCC ACAGCCACCA TCACCAGTAC TGGGCCCAGC CTCTTTGCGT CAATAGCAAC TGCTCCAACC TCATCTGCCA CCACTGGACT CTCCCTCTGT ACCCCTGTGA CCACAGCGGG CGCCCCCACT GCTGGGACAC AGGGCTTCAG CTTAAAGGCA CCTGGAGCAG CTTCCGGCAC CTCCACAACA ACATCCACCG CTGCCACCGC CACCGCCACC ACCACCACCA GCAGCAGCAC CACCGGCTTT GCCTTGAATT TAAAACCACT GGCGCCAGCC GGGATCCCCA GCAATACAGC AGCTGCCGTG ACCGCTCCAC CTGGCCCTGG CGCAGCTGCA GGGGCGGCTG CCAGCTCCGC CATGACCTAC GCGCAGCTGG AGAGCCTGAT CAACAAATGG AGCCTGGAGC TAGAGGACCA GGAGCGGCAC TTCCTCCAGC AGGCCACCCA GGTCAACGCC TGGGACCGCA CGCTGATCGA GAATGGAGAA AAGATCACCA GCCTGCACCG CGAGGTGGAG AAGGTGAAGC TGGACCAGAA GAGGCTGGAC CAGGAGCTCG ACTTCATCCT GTCCCAGCAG AAGGAGCTGG AAGACCTGCT GAGCCCACTG GAGGAGTTGG TCAAGGAGCA GAGCGGGACC ATCTACCTGC AGCACGCGGA TGAGGAGCGT GAGAAAACCT ACAAGCTGGC TGAGAACATC GACGCACAGC TCAAGCGCAT GGCCCAGGAT CTCAAGGACA TCATCGAGCA CCTGAACACG TCCGGGGCCC CCGCCGACAC CAGTGACCCA CTGCAGCAGA TCTGCAAGAT CCTCAATGCG CACATGGACT CACTGCAGTG GATCGACCAG AACTCGGCCC TGCTGCAGAG GAAGGTGGAG GAGGTGACCA AGGTGTGCGA GGGCCGGCGC AAGGAGCAGG AGCGCAGCTT CCGGATCACC TTTGACTGA. It is sometimes possible for the material contained within the vial of "NUP62, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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