Rabbit NUP160 Polyclonal Antibody | anti-NUP160 antibody

NUP160 Antibody

Cat. Num. AAA150987

• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: NUP160 Antibody is affinity chromatography purified via peptide column.
• Synonyms: NUP160; Polyclonal Antibody; NUP160 Antibody; KIAA0197; NUP120; Nuclear pore complex protein Nup160; 160 kDa nucleoporin; nucleoporin 160kDa; anti-NUP160 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: NUP160 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 224

• Applicable Applications for anti-NUP160 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: NUP160 antibody can be used for detection of NUP160 by Western blot at 0.5 - 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.
• Conjugate: Unconjugated
• Immunogen: NUP160 antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human NUP160.
• Buffer: NUP160 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: NUP160 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of NUP160 in rat brain tissue lysate with NUP160 antibody at (A) 0.5 and (B) 1 μg/mL.)

Immunohistochemistry (IHC)

(Immunohistochemistry of NUP160 in human brain tissue with NUP160 antibody at 2.5 μg/mL.)

Immunofluorescence (IF)

(Immunofluorescence of NUP160 in Human Brain cells with NUP160 antibody at 20 μg/mL.)

Related Product Information for anti-NUP160 antibody

NUP160 Antibody: The nuclear pore complex (NPC) is a protein assembly localized at the nuclear rim and mediates macromolecular transport between the nucleus and the cytoplasm. The mammalian nucleoporin (NUP)-160 is part of the hetero-oligomeric complex that also contains NUP107, NUP133, NUP96, and mammalian homolog of yeast sec13p. While the majority of the NUP107-160 nuclear pore sub-complex localizes to the nuclear pore, a small fraction is observed at kinetochores and pro-metaphase spindle poles in mitotic cells in association with proteins such as Mad1, Mad2, Bub3 and Cdc20. Immunodepletion of the NUP107-160 complex resulted in defective spindle assembly indicating that it has multiple functions. NUP160 has recently been identified as an HIV dependency factor (HDF), suggesting that NUP160 may be an important drug target in HIV treatment. Multiple isoforms of NUP160 are known to exist.

NCBI and Uniprot Product Information

• NCBI GI #: 119588287
• NCBI GeneID: 23279
• UniProt Accession #: Q12769; Q08AD3; Q7Z5X6; Q96GB3; Q9H660; B4DYE8; B4E2J9
• Molecular Weight: 55,554 Da
• NCBI Official Full Name: nucleoporin 160kDa, isoform CRA_d
• NCBI Official Synonym Full Names: nucleoporin 160kDa
• NCBI Official Symbol: NUP160
• NCBI Protein Information: nuclear pore complex protein Nup160; nucleoporin 160kD; nucleoporin Nup160; 160 kDa nucleoporin
• UniProt Protein Name: Nuclear pore complex protein Nup160
• Protein Family: Nuclear pore complex protein
• UniProt Gene Name: NUP160
• UniProt Synonym Gene Names: KIAA0197; NUP120
• UniProt Entry Name: NU160_HUMAN

NCBI Description

NUP160 is 1 of up to 60 proteins that make up the 120-MD nuclear pore complex, which mediates nucleoplasmic transport.[supplied by OMIM, Apr 2004]

Uniprot Description

NUP160: Involved in poly(A)+ RNA transport. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Nucleoporin

Chromosomal Location of Human Ortholog: 11p11.2

Cellular Component: kinetochore; nuclear pore; nuclear envelope; cytosol

Molecular Function: protein binding; nucleocytoplasmic transporter activity

Biological Process: viral reproduction; cytokine and chemokine mediated signaling pathway; mitotic nuclear envelope disassembly; pathogenesis; viral infectious cycle; glucose transport; protein transport; mRNA export from nucleus; hexose transport; carbohydrate metabolic process; viral transcription; gene expression; mitotic cell cycle; transmembrane transport