Rabbit NUDT2 Polyclonal Antibody | anti-NUDT2 antibody

NUDT2 Rabbit Polyclonal

Cat. Num. AAA7602136

• Gene Names: NUDT2; APAH1
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: NUDT2; Polyclonal Antibody; NUDT2 Rabbit Polyclonal; anti-NUDT2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 147

• Applicable Applications for anti-NUDT2 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: Nudix (nucleoside diphosphate linked moiety X)-type motif 2
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human breast cancer using MBS7602136 (NUDT2 antibody) at dilution of 1:100)

Western Blot (WB)

(mouse liver tissue were subjected to SDS PAGE followed by western blot with MBS7602136 (NUDT2 antibody) at dilution of 1:1500)

NCBI and Uniprot Product Information

• NCBI GI #: 346986334
• NCBI GeneID: 318
• NCBI Accession #: NP_001231319.1
• NCBI GenBank Nucleotide #: NM_001244390.1
• Molecular Weight: 16,829 Da
• NCBI Official Full Name: NUDT2 gene product
• NCBI Official Synonym Full Names: nudix hydrolase 2
• NCBI Official Symbol: NUDT2
• NCBI Official Synonym Symbols: APAH1
• NCBI Protein Information: bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]
• UniProt Protein Name: Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]
• Protein Family: Nudix hydrolase
• UniProt Gene Name: NUDT2
• UniProt Synonym Gene Names: APAH1; Ap4A hydrolase; Ap4Aase; Diadenosine tetraphosphatase; Nudix motif 2
• UniProt Entry Name: AP4A_HUMAN

NCBI Description

This gene encodes a member of the MutT family of nucleotide pyrophosphatases, a subset of the larger NUDIX hydrolase family. The gene product possesses a modification of the MutT sequence motif found in certain nucleotide pyrophosphatases. The enzyme asymmetrically hydrolyzes Ap4A to yield AMP and ATP and is responsible for maintaining the intracellular level of the dinucleotide Ap4A, the function of which has yet to be established. This gene may be a candidate tumor suppressor gene. Alternative splicing has been observed at this locus and four transcript variants, all encoding the same protein, have been identified. [provided by RefSeq, Sep 2011]

Uniprot Description

NUDT2: Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis. Belongs to the Nudix hydrolase family.

Protein type: Hydrolase; Nucleotide Metabolism - pyrimidine; Apoptosis; Nucleotide Metabolism - purine; EC 3.6.1.17

Chromosomal Location of Human Ortholog: 9p13

Cellular Component: mitochondrial matrix

Molecular Function: bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity; bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity; GTP binding; protein binding

Biological Process: apoptosis; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; response to reactive oxygen species