Rabbit anti-Human NTH1 Polyclonal Antibody | anti-NTH1 antibody
NTH1 Antibody BIOTIN-Conjugated
ELISA: 1:10,000
Western Blot: 1:500
Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a DNA N-glycosylase of the endonuclease III family. Like a similar protein in E. coli, the encoded protein has DNA glycosylase activity on DNA substrates containing oxidized pyrimidine residues and has apurinic/apyrimidinic lyase activity. [provided by RefSeq, Oct 2008]
Uniprot Description
NTHL1: Has both an apurinic and/or apyrimidinic endonuclease activity and a DNA N-glycosylase activity. Incises damaged DNA at cytosines, thymines and guanines. Acts on a damaged strand, 5' from the damaged site. Required for the repair of both oxidative DNA damage and spontaneous mutagenic lesions. Belongs to the Nth/MutY family.
Protein type: DNA repair, damage; Hydrolase; Lyase; Mitochondrial; EC 4.2.99.18
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component: mitochondrion; nucleoplasm; nucleus
Molecular Function: 4 iron, 4 sulfur cluster binding; DNA N-glycosylase activity; DNA-(apurinic or apyrimidinic site) lyase activity; double-stranded DNA binding; endonuclease activity; metal ion binding; oxidized purine base lesion DNA N-glycosylase activity; oxidized pyrimidine base lesion DNA N-glycosylase activity; protein binding
Biological Process: base-excision repair, AP site formation; depyrimidination; nucleotide-excision repair, DNA incision, 5'-to lesion; positive regulation of defense response to virus by host
Disease: Familial Adenomatous Polyposis 3
Research Articles on NTH1
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Product Notes
The NTH1 nthl1 (Catalog #AAA542251) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The NTH1 Antibody BIOTIN-Conjugated reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's NTH1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Dot Blot: 1:10,000 ELISA: 1:10,000 Western Blot: 1:500. Researchers should empirically determine the suitability of the NTH1 nthl1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NTH1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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