Rabbit anti-Human, Mouse NTAN1 Polyclonal Antibody | anti-NTAN1 antibody

NTAN1 Antibody

Cat. Num. AAA9430358

• Gene Names: NTAN1; PNAA; PNAD
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: NTAN1; Polyclonal Antibody; NTAN1 Antibody; PNAA; PNAD; anti-NTAN1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: The antibody detects endogenous levels of total NTAN1 protein.
• Purity/Purification: Antigen affinity purification
• Form/Format: pH 7.4 PBS, 0.05% NaN3, 40% Glycerol
• Concentration: 1.3 mg/mL (varies by lot)
• Sequence Length: 205

• Applicable Applications for anti-NTAN1 antibody: Immunohistochemistry (IHC)
• Application Notes: IHC: 1:50-300
• Immunogen: Fusion protein of human NTAN1
• Immunogen Type: Peptide
• Preparation and Storage: Store at -20 degree C.

Immunohistochemistry (IHC)

(The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using 47376(NTAN1 Antibody) at dilution 1/50.(Original magnification: 200))

Immunohistochemistry (IHC)

(The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using 47376(NTAN1 Antibody) at dilution 1/50.(Original magnification: 200))

Related Product Information for anti-NTAN1 antibody

The protein encoded by this gene functions in a step-wise process of protein degradation through the N-end rule pathway. This protein acts as a tertiary destabilizing enzyme that deamidates N-terminal L-Asn residues on proteins to produce N-terminal L-Asp. L-Asp substrates are subsequently conjugated to L-Arg, which is recognized by specific E3 ubiquitin ligases and targeted to the proteasome. Pseudogenes of this gene are located on the long arms of chromosomes 8, 10 and 12. Alternative splicing results in multiple transcript variants that encode different protein isoforms.

Product Categories/Family for anti-NTAN1 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 399124760
• NCBI GeneID: 123803
• NCBI Accession #: NP_001257695.1
• NCBI GenBank Nucleotide #: NM_001270766.1
• UniProt Accession #: Q96AB6; Q7Z4Z0
• Molecular Weight: 34,677 Da
• NCBI Official Full Name: protein N-terminal asparagine amidohydrolase isoform 2
• NCBI Official Synonym Full Names: N-terminal asparagine amidase
• NCBI Official Symbol: NTAN1
• NCBI Official Synonym Symbols: PNAA; PNAD
• NCBI Protein Information: protein N-terminal asparagine amidohydrolase
• UniProt Protein Name: Protein N-terminal asparagine amidohydrolase
• Protein Family: Protein N-terminal asparagine amidohydrolase
• UniProt Gene Name: NTAN1
• UniProt Synonym Gene Names: PNAA; PNAD; Protein N-terminal Asn amidase; Protein N-terminal asparagine amidase; Protein NTN-amidase

NCBI Description

The protein encoded by this gene functions in a step-wise process of protein degradation through the N-end rule pathway. This protein acts as a tertiary destabilizing enzyme that deamidates N-terminal L-Asn residues on proteins to produce N-terminal L-Asp. L-Asp substrates are subsequently conjugated to L-Arg, which is recognized by specific E3 ubiquitin ligases and targeted to the proteasome. Pseudogenes of this gene are located on the long arms of chromosomes 8, 10 and 12. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

Uniprot Description

N-terminal asparagine deamidase that mediates deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N-terminal asparagine to aspartate by NTAN1/PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. This enzyme does not act on substrates with internal or C-terminal asparagines and does not act on glutamine residues in any position, nor on acetylated N-terminal peptidyl Asn.