Western Blot (WB)
(Western Blot analysis of nSMase in Mouse lung tissue lysate using nSMase Rabbit pAb at dilution 1/1000)
Rabbit nSMase Polyclonal Antibody | anti-nSMase antibody
nSMase Rabbit pAb
IHC-P: 1:50-1:300
Western Blot (WB)
(Western Blot analysis of nSMase in Mouse lung tissue lysate using nSMase Rabbit pAb at dilution 1/1000)
Western Blot (WB)
(Western Blot analysis of nSMase in Mouse lung tissue lysate using nSMase Rabbit pAb at dilution 1/1000)
Immunohistochemistry (IHC)
(Immunohistochemistry of nSMase in paraffin-embedded Human brain tissue using nSMase Rabbit pAb at dilution 1/90. Predicted cell location: Cytoplasm)
Immunohistochemistry (IHC)
(Immunohistochemistry of nSMase in paraffin-embedded Human brain tissue using nSMase Rabbit pAb at dilution 1/90. Predicted cell location: Cytoplasm)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein which was initially identified as a sphingomyelinase based on sequence similarity between bacterial sphingomyelinases and a yeast protein. Subsequent studies showed that its biological function is less likely to be as a sphingomyelinase and instead as a lysophospholipase. [provided by RefSeq, Oct 2009]
Uniprot Description
SMPD2: Converts sphingomyelin to ceramide. Hydrolyze 1-acyl-2- lyso-sn-glycero-3-phosphocholine (lyso-PC) and 1-O-alkyl-2-lyso- sn-glycero-3-phosphocholine (lyso-platelet-activating factor). The physiological substrate seems to be Lyso-PAF. Belongs to the neutral sphingomyelinase family.
Protein type: Membrane protein, integral; Phosphodiesterase; Lipid Metabolism - sphingolipid; Membrane protein, multi-pass; EC 3.1.4.12
Chromosomal Location of Human Ortholog: 6q21
Cellular Component: integral to plasma membrane; plasma membrane; caveola
Molecular Function: sphingomyelin phosphodiesterase activity; metal ion binding
Biological Process: sphingolipid metabolic process; sphingomyelin metabolic process; nerve growth factor receptor signaling pathway; response to mechanical stimulus; ceramide biosynthetic process; glycosphingolipid metabolic process
Research Articles on nSMase
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Product Notes
The nSMase smpd2 (Catalog #AAA4759308) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The nSMase Rabbit pAb reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's nSMase can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P). WB: 1:1000-1:5000 IHC-P: 1:50-1:300. Researchers should empirically determine the suitability of the nSMase smpd2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "nSMase, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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