Rabbit anti-Human NSE4A Polyclonal Antibody | anti-NSE4A antibody
NSE4A, NT (NSMCE4A, C10orf86, Non-structural maintenance of chromosomes element 4 homolog A) (MaxLight 490)
Gene Names
NSMCE4A; NS4EA; NSE4A; C10orf86
Reactivity
Human
Applications
Western Blot
Purity
Purified by Protein A Affinity Chromatography.
Synonyms
NSE4A; Polyclonal Antibody; NT (NSMCE4A; C10orf86; Non-structural maintenance of chromosomes element 4 homolog A) (MaxLight 490); NSMCE4A; Non-structural maintenance of chromosomes element 4 homolog A; anti-NSE4A antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Purified by Protein A Affinity Chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight490.
Applicable Applications for anti-NSE4A antibody
Western Blot (WB), FLISA
Application Notes
WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.
FLISA: 1:1,000
Applications are based on unconjugated antibody.
Immunogen
NSE4A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 36~65 amino acids from the N-terminal region of human NSE4A.
Conjugate
MaxLight490
Note
Preservative Free
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight490 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Related Product Information for anti-NSE4A antibody
MaxLight490 is a new Blue-Green photostable dye conjugate comparable to DyLight488, Alexa Fluor488 and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (491nm); Emission (515nm); Extinction Coefficient 73,000.
Product Categories/Family for anti-NSE4A antibody
References
Hu, B., et al. Mol. Microbiol. 55(6):1735-1750(2005).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
44,301 Da
NCBI Official Full Name
non-structural maintenance of chromosomes element 4 homolog A isoform 2
NCBI Official Synonym Full Names
non-SMC element 4 homolog A (S. cerevisiae)
NCBI Official Symbol
NSMCE4A
NCBI Official Synonym Symbols
NS4EA; NSE4A; C10orf86
NCBI Protein Information
non-structural maintenance of chromosomes element 4 homolog A
UniProt Protein Name
Non-structural maintenance of chromosomes element 4 homolog A
Protein Family
UniProt Gene Name
NSMCE4A
UniProt Synonym Gene Names
C10orf86; NS4EA
UniProt Entry Name
NSE4A_HUMAN
Uniprot Description
Function: Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Is involved in positive regulation of response to DNA damage stimulus. Ref.7
Subunit structure: Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3 and NDNL2. NSMCE1, NSMCE4A or EID3 and NDNL2 probably form a subcomplex that bridges the head domains of the SMC5:SMC6 heterodimer. Ref.7
Subcellular location: Nucleus. Chromosome › telomere
Probable Ref.7.
Sequence similarities: Belongs to the NSE4 family.
Similar Products
Product Notes
The NSE4A nsmce4a (Catalog #AAA6326859) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The NSE4A, NT (NSMCE4A, C10orf86, Non-structural maintenance of chromosomes element 4 homolog A) (MaxLight 490) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's NSE4A can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), FLISA. WB: 1:100-500 FLISA: 1:1,000 Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the NSE4A nsmce4a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NSE4A, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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