Rabbit anti-Human NRG4 Polyclonal Antibody | anti-NRG4 antibody

NRG4 Antibody

Cat. Num. AAA7006703

• Gene Names: NRG4; HRG4
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry, Immunofluorescence
• Purity: >95%,Protein G purified
• Synonyms: NRG4; Polyclonal Antibody; NRG4 Antibody; Pro-neuregulin-4; membrane-bound isoform; Pro-NRG4Cleaved into the following chain:Neuregulin-4; NRG-4; anti-NRG4 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%,Protein G purified
• Form/Format: Liquid
• Sequence Length: 115

• Applicable Applications for anti-NRG4 antibody: ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Immunogen: Recombinant human Pro-neuregulin-4, membrane-bound isoform protein
• Conjugation: Non-conjugated
• Storage Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Preparation and Storage: Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human kidney tissue using MBS7006703 at dilution of 1:100)

Immunofluorescence (IF)

(Immunofluorescent analysis of Hela cells using MBS7006703 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))

Related Product Information for anti-NRG4 antibody

Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors.

NCBI and Uniprot Product Information

• NCBI GI #: 20070380
• NCBI GeneID: 145957
• NCBI Accession #: NP_612640.1
• NCBI GenBank Nucleotide #: NM_138573.3
• UniProt Accession #: Q8WWG1; A6NIE8
• Molecular Weight: 12,722 Da
• NCBI Official Full Name: pro-neuregulin-4, membrane-bound isoform
• NCBI Official Synonym Full Names: neuregulin 4
• NCBI Official Symbol: NRG4
• NCBI Official Synonym Symbols: HRG4
• NCBI Protein Information: pro-neuregulin-4, membrane-bound isoform
• UniProt Protein Name: Pro-neuregulin-4, membrane-bound isoform
• Protein Family: Pro-neuregulin
• UniProt Gene Name: NRG4
• UniProt Synonym Gene Names: Pro-NRG4; NRG-4
• UniProt Entry Name: NRG4_HUMAN

NCBI Description

The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]).[supplied by OMIM, Mar 2008]

Uniprot Description

NRG4: Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors. Belongs to the neuregulin family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 15q24.2

Cellular Component: extracellular region; extracellular space; integral to membrane; intracellular; plasma membrane

Molecular Function: growth factor activity; protein binding; receptor binding

Biological Process: activation of MAPKK activity; axon guidance; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; innate immune response; insulin receptor signaling pathway; MAPKKK cascade; nerve growth factor receptor signaling pathway; organ development; phosphoinositide-mediated signaling; Ras protein signal transduction; small GTPase mediated signal transduction; vascular endothelial growth factor receptor signaling pathway