Rabbit anti-Human NRG2 Polyclonal Antibody | anti-NRG2 antibody

NRG2, CT (Neuregulin 2, Pro-neuregulin-2, Membrane-bound Isoform, Pro-NRG2, Neuregulin-2, NTAK)

Cat. Num. AAA625714

• Gene Names: NRG2; DON1; HRG2; NTAK
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: NRG2; Polyclonal Antibody; CT (Neuregulin 2; Pro-neuregulin-2; Membrane-bound Isoform; Pro-NRG2; Neuregulin-2; NTAK); Anti -NRG2; anti-NRG2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human NRG2.
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.09% sodium azide.

• Applicable Applications for anti-NRG2 antibody: ELISA (EL/EIA), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in ELISA and Immunohistochemistry.; Dilution: ELISA: 1:1000; Immunohistochemistry: 1:50-1:100
• Immunogen: Synthetic peptides between 366~396 amino acids from the C-terminal region (aa834-850) and center region (aa 373-389) from human NRG2, conjugated to KLH.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunohistochemistry (IHC)

(Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.)

Related Product Information for anti-NRG2 antibody

Neuregulin 2 (NRG2) is a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the Erbb family of receptors, NRG2 induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1 (NRG1), another member of the neuregulin family of ligands. NRG1 and NRG2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. There are six NRG2 alternatively spliced transcripts which are variable between the epidermal growth factor-like (EGF-like) and the transmembrane domains. The gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease.

Product Categories/Family for anti-NRG2 antibody

Antibodies; Abs to Growth Factors; Cytokines

NCBI and Uniprot Product Information

• NCBI GI #: 133777750
• NCBI GeneID: 9542
• UniProt Accession #: Q3MI86; O14511
• Molecular Weight: 31,088 Da
• NCBI Official Full Name: NRG2 protein
• NCBI Official Synonym Full Names: neuregulin 2
• NCBI Official Symbol: NRG2
• NCBI Official Synonym Symbols: DON1; HRG2; NTAK
• NCBI Protein Information: pro-neuregulin-2, membrane-bound isoform; pro-NRG2; OTTHUMP00000159546; OTTHUMP00000198728; OTTHUMP00000224194; OTTHUMP00000224196; OTTHUMP00000230686; divergent of neuregulin-1; neural- and thymus-derived activator for ErbB kinases
• UniProt Protein Name: NRG2 protein
• Protein Family: Pro-neuregulin
• UniProt Gene Name: NRG2
• UniProt Entry Name: Q3MI86_HUMAN

NCBI Description

This gene encodes a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ERBB family of receptors, this protein induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1, another member of the neuregulin family of ligands. The products of these genes mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. This gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcript variants encoding distinct isoforms have been described. [provided by RefSeq]

Uniprot Description

NRG2: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor. Belongs to the neuregulin family. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Ligand, receptor tyrosine kinase; Membrane protein, integral

Chromosomal Location of Human Ortholog: 5q31.2

Cellular Component: extracellular space; plasma membrane; extracellular region; integral to membrane

Molecular Function: growth factor activity; receptor binding

Biological Process: epidermal growth factor receptor signaling pathway; embryonic development; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; organ development; innate immune response; signal transduction