Rabbit NRDP1 Polyclonal Antibody | anti-NRDP1 antibody

NRDP1 (V276) Polyclonal Antibody

Cat. Num. AAA3000289

• Gene Names: RNF41; FLRF; NRDP1; SBBI03
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE)
• Synonyms: NRDP1; Polyclonal Antibody; NRDP1 (V276) Polyclonal Antibody; E3 ubiquitin-protein ligase NRDP1; RING finger protein 41; anti-NRDP1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: NRDP1 (V276) polyclonal antibody detects endogenous levels of NRDP1 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE)
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 317

• Applicable Applications for anti-NRDP1 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: Synthetic peptide, corresponding to amino acids 250-300 of Human NRDP1.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of NRDP1 (V276) polyclonal antibody at 1:500 dilutionLane1:The testis tissue lysate of Rat (40ug) Lane2:The testis tissue lysate of Mouse (40ug) Lane3:HCT116 whole cell lysate (40ug) Lane4:SK-OVCAR3 whole cell lysate (40ug))

Related Product Information for anti-NRDP1 antibody

The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. Nrdp1, also known as RNF41 (RING finger protein 41), SBBI03 or FLRF, is a 317 amino acid protein that contains one RING-type zinc finger and one SIAH-type zinc finger. Expressed in testis, ovary and prostate, Nrdp1 functions as an E3 ubiquitin-protein ligase that, characteristic of E3 ligase proteins, accepts ubiquitin (in the form of a thioester) from an E2 ubiquitin-conjugating enzyme and transfers that ubiquitin residue to substrates targeted for degradation. Specifically, Nrdp1 interacts with ErbB-3 and UBPY, thereby targeting them for proteasomal degradation.

NCBI and Uniprot Product Information

• NCBI GI #: 338827618
• NCBI GeneID: 10193
• NCBI Accession #: NP_001229755
• NCBI GenBank Nucleotide #: NP_001229755.1
• UniProt Accession #: Q9H4P4
• Molecular Weight: ~ 36kDa
• NCBI Official Full Name: E3 ubiquitin-protein ligase NRDP1 isoform 1
• NCBI Official Synonym Full Names: ring finger protein 41
• NCBI Official Symbol: RNF41
• NCBI Official Synonym Symbols: FLRF; NRDP1; SBBI03
• NCBI Protein Information: E3 ubiquitin-protein ligase NRDP1
• UniProt Protein Name: E3 ubiquitin-protein ligase NRDP1
• UniProt Gene Name: RNF41
• UniProt Synonym Gene Names: FLRF; NRDP1
• UniProt Entry Name: RNF41_HUMAN

NCBI Description

This gene encodes an E3 ubiquitin ligase. The encoded protein plays a role in type 1 cytokine receptor signaling by controlling the balance between JAK2-associated cytokine receptor degradation and ectodomain shedding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011]