Rabbit anti-Human, Rat NRBF2 Polyclonal Antibody | anti-NRBF2 antibody

NRBF2 Polyclonal Antibody

Cat. Num. AAA3011587

• Gene Names: NRBF2; COPR; COPR1; COPR2; NRBF-2
• Reactivity: Human, Rat
• Applications: Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: NRBF2; Polyclonal Antibody; NRBF2 Polyclonal Antibody; Nuclear receptor-binding factor 2; NRBF-2; Comodulator of PPAR and RXR; COPR; anti-NRBF2 antibody

• Host: Rabbit
• Reactivity: Human, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: NRBF2 polyclonal antibody detects endogenous levels of NRBF2 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 287

• Applicable Applications for anti-NRBF2 antibody: Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: WB: 1:500-1:2000; IHC: 1:50-1:200
• Immunogen: Recombinant full length Human NRBF2.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of NRBF2 polyclonal antibody)

Related Product Information for anti-NRBF2 antibody

Nuclear hormone receptors function as transcriptional activators when their cognate ligands are bound. Binding of the appropriate ligand induces a conformational change in the nuclear receptor, allowing it to interact with transcriptional coactivators. NRBF2 (Nuclear receptor-binding factor 2), also known as COPR (Comodulator of PPAR and RXR), is thought to act as a transcriptional coactivator by altering the activity of target nuclear receptors. Highly expressed in the liver, placenta and keratinocytes, NRBF2 can interact with at least 7 nuclear receptors including PPARalpha, PPARdelta and PPARgamma. In the presence of a bound ligand, NRBF2 can interact with nuclear receptors RARalpha, RARgamma. and RXRalpha. NRBF2, which exists as two isoforms due to alternative splicing, is localized to both the nucleus and the cytoplasm.

NCBI and Uniprot Product Information

• NCBI GI #: 156231355
• NCBI GeneID: 29982
• NCBI Accession #: NP_110386.2
• NCBI GenBank Nucleotide #: NP_110386.2
• UniProt Accession #: Q96F24
• Molecular Weight: ~ 38kDa
• NCBI Official Full Name: nuclear receptor-binding factor 2 isoform 1
• NCBI Official Synonym Full Names: nuclear receptor binding factor 2
• NCBI Official Symbol: NRBF2
• NCBI Official Synonym Symbols: COPR; COPR1; COPR2; NRBF-2
• NCBI Protein Information: nuclear receptor-binding factor 2
• UniProt Protein Name: Nuclear receptor-binding factor 2
• Protein Family: Nuclear receptor-binding factor
• UniProt Gene Name: NRBF2
• UniProt Synonym Gene Names: COPR; NRBF-2
• UniProt Entry Name: NRBF2_HUMAN

Uniprot Description

NRBF2: May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro). Interacts with PPARA, PPARD and PPARG. Interacts with RARA, RARG and RXRA in the presence of bound ligand. Detected in keratinocytes, liver and placenta. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Autophagy; Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 10q21.3

Cellular Component: nucleoplasm; cytoplasm

Biological Process: transcription initiation from RNA polymerase II promoter; regulation of transcription, DNA-dependent; gene expression