Western Blot (WB)
(Host: RabbitTarget Name: NR2E1Sample Type: THP-1 Whole cell lysatesAntibody Dilution: 1.0ug/ml)
Rabbit NR2E1 Polyclonal Antibody | anti-NR2E1 antibody
NR2E1 Antibody - C-terminal region
Western Blot (WB)
(Host: RabbitTarget Name: NR2E1Sample Type: THP-1 Whole cell lysatesAntibody Dilution: 1.0ug/ml)
Western Blot (WB)
(Host: RabbitTarget Name: NR2E1Sample Type: THP-1 Whole cell lysatesAntibody Dilution: 1.0ug/ml)
Target Description: The NR2E1 gene is a member of the steroid nuclear receptor superfamily and is predominately expressed in the brain. The contributions of this gene to human B-cell leukemia and to brain development are unknown at present.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is an orphan receptor involved in retinal development. The encoded protein also regulates adult neural stem cell proliferation and may be involved in control of aggressive behavior. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
Uniprot Description
NR2E1: Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half- site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity. May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity. May be involved in retinoic acic receptor (RAR) regulation in retinal cells. Belongs to the nuclear hormone receptor family. NR2 subfamily.
Protein type: DNA-binding; Nuclear receptor
Chromosomal Location of Human Ortholog: 6q21
Cellular Component: nucleoplasm
Molecular Function: zinc ion binding; sequence-specific DNA binding; histone deacetylase binding; steroid hormone receptor activity
Biological Process: extracellular matrix organization and biogenesis; behavioral fear response; somatic stem cell maintenance; regulation of dendrite morphogenesis; regulation of timing of neuron differentiation; negative regulation of transcription from RNA polymerase II promoter; amygdala development; cerebral cortex neuron differentiation; visual perception; layer formation in the cerebral cortex; nervous system development; transcription initiation from RNA polymerase II promoter; dentate gyrus development; cell fate commitment; generation of neurons in the forebrain; olfactory bulb development; positive regulation of cell cycle; social behavior; negative regulation of neuron differentiation; positive regulation of angiogenesis; anterior commissure morphogenesis; retina development in camera-type eye; negative regulation of astrocyte differentiation; steroid hormone mediated signaling; gene expression; positive regulation of transcription from RNA polymerase II promoter; negative regulation of apoptosis
Research Articles on NR2E1
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Product Notes
The NR2E1 nr2e1 (Catalog #AAA3207820) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The NR2E1 Antibody - C-terminal region reacts with Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish and may cross-react with other species as described in the data sheet. AAA Biotech's NR2E1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the NR2E1 nr2e1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Synthetic peptide located within the following region: TEFACLKCIV TFKAVPTHSG SELRSFRNAA AIAALQDEAQ LTLNSYIHTR. It is sometimes possible for the material contained within the vial of "NR2E1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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