Rabbit NR2C2 Polyclonal Antibody | anti-NR2C2 antibody

NR2C2 antibody

Cat. Num. AAA9409048

• Gene Names: NR2C2; TR4; TAK1
• Applications: Western Blot
• Purity: Antibodies were purified by affinity purification using immunogen.
• Synonyms: NR2C2; Polyclonal Antibody; NR2C2 antibody; TR4; TAK1; anti-NR2C2 antibody

• Host: Rabbit
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous level of total NR2C2 antibody.
• Purity/Purification: Antibodies were purified by affinity purification using immunogen.
• Form/Format: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 596

• Applicable Applications for anti-NR2C2 antibody: Western Blot (WB)
• Application Notes: Western blotting: 1:500 - 1:2000
• Immunogen Type: Recombinant Protein
• Immunogen Description: Recombinant protein of human NR2C2.
• Target Name: NR2C2
• Preparation and Storage: Store at -20 degree C

Western Blot (WB)

(Western blot analysis of extracts of various cell lines, using NR2C2 antibody.)

Related Product Information for anti-NR2C2 antibody

This gene encodes a protein that belongs to the nuclear hormone receptor family. Members of this family act as ligand-activated transcription factors and function in many biological processes such as development, cellular differentiation and homeostasis. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes. The protein encoded by this gene plays a role in protecting cells from oxidative stress and damage induced by ionizing radiation. The lack of a similar gene in mouse results in growth retardation, severe spinal curvature, subfertility, premature aging, and prostatic intraepithelial neoplasia (PIN) development. Alternative splicing results in multiple transcript variants encoding different isoforms.

Product Categories/Family for anti-NR2C2 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 619329027
• NCBI GeneID: 7182
• NCBI Accession #: NP_001278623.1
• NCBI GenBank Nucleotide #: NM_001291694.1
• UniProt Accession #: P49116; P55092; A8K3H5; B6ZGT8
• Molecular Weight: 67,345 Da
• NCBI Official Full Name: nuclear receptor subfamily 2 group C member 2 isoform 2
• NCBI Official Synonym Full Names: nuclear receptor subfamily 2, group C, member 2
• NCBI Official Symbol: NR2C2
• NCBI Official Synonym Symbols: TR4; TAK1
• NCBI Protein Information: nuclear receptor subfamily 2 group C member 2
• UniProt Protein Name: Nuclear receptor subfamily 2 group C member 2
• Protein Family: Nuclear receptor subfamily
• UniProt Gene Name: NR2C2
• UniProt Synonym Gene Names: TAK1; TR4
• UniProt Entry Name: NR2C2_HUMAN

NCBI Description

This gene encodes a protein that belongs to the nuclear hormone receptor family. Members of this family act as ligand-activated transcription factors and function in many biological processes such as development, cellular differentiation and homeostasis. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes. The protein encoded by this gene plays a role in protecting cells from oxidative stress and damage induced by ionizing radiation. The lack of a similar gene in mouse results in growth retardation, severe spinal curvature, subfertility, premature aging, and prostatic intraepithelial neoplasia (PIN) development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]

Uniprot Description

NR2C2: Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear recptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior. Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation. Belongs to the nuclear hormone receptor family. NR2 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor; DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 3p25

Cellular Component: nucleoplasm

Molecular Function: protein binding; zinc ion binding; protein heterodimerization activity; sequence-specific DNA binding; transcription coactivator activity; steroid hormone receptor activity; receptor activity; transcription factor activity

Biological Process: nervous system development; transcription initiation from RNA polymerase II promoter; positive regulation of embryonic development; meiotic cell cycle; regulation of transcription, DNA-dependent; positive regulation of behavior; cerebellum development; spermatogenesis; gene expression; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling; cell differentiation