Western Blot (WB)
(Gel: 10%SDS-PAGE, Lysate: 40 ug, Lane: Human hepatocellular carcinoma tissue, Primary antibody: 861973(NPHS2 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes)
Rabbit anti-Human NPHS2 Polyclonal Antibody | anti-NPHS2 antibody
NPHS2 Rabbit pAb
IHC: 1:50-1:200
Western Blot (WB)
(Gel: 10%SDS-PAGE, Lysate: 40 ug, Lane: Human hepatocellular carcinoma tissue, Primary antibody: 861973(NPHS2 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes)
Western Blot (WB)
(Gel: 10%SDS-PAGE, Lysate: 40 ug, Lane: Human hepatocellular carcinoma tissue, Primary antibody: 861973(NPHS2 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes)
Immunohistochemistry (IHC)
(The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using 861973(NPHS2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200))
Immunohistochemistry (IHC)
(The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using 861973(NPHS2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200))
NCBI and Uniprot Product Information
Uniprot Description
NPHS2: Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton. Defects in NPHS2 are the cause of nephrotic syndrome type 2 (NPHS2). It is a renal disorder characterized clinically by childhood onset of proteinuria, hypoalbuminemia, hyperlipidemia, and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. The disorder is resistant to steroid treatment and progresses to end-stage renal failure in the first or second decades. Some patients show later onset of the disorder. Belongs to the band 7/mec-2 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 1q25.2
Cellular Component: protein complex; endoplasmic reticulum; integral to plasma membrane; plasma membrane; intercellular junction; lipid raft
Molecular Function: protein binding
Biological Process: actin cytoskeleton reorganization; excretion
Disease: Nephrotic Syndrome, Type 2
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Product Notes
The NPHS2 nphs2 (Catalog #AAA4758494) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The NPHS2 Rabbit pAb reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's NPHS2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P). WB: 1:200-1:1000 IHC: 1:50-1:200. Researchers should empirically determine the suitability of the NPHS2 nphs2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NPHS2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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