Rabbit NPFF2 / NPFFR2 Polyclonal Antibody | anti-NPFF2 antibody

Rabbit Polyclonal to Human NPFF2 / NPFFR2

Cat. Num. AAA244632

• Gene Names: NPFFR2; GPR74; NPFF2; NPGPR; HLWAR77
• Reactivity: Gorilla, Human; Predicted Reactivity: Gibbon (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: NPFF2 / NPFFR2; Polyclonal Antibody; Rabbit Polyclonal to Human NPFF2 / NPFFR2; Anti-NPFF2 / NPFFR2 Antibody (N-Terminus) IHC-plus; NPFFR2; G protein-coupled receptor 74; HLWAR77; G-protein coupled receptor 74; Neuropeptide FF receptor 2; Neuropeptide FF 2; NPFF2; Neuropeptide FF 2 receptor; NPGPR; GPR74; NPFF-R2; NPFF2 receptor; NPGP receptor; Human NPFF2; anti-NPFF2 antibody

• Host: Rabbit
• Reactivity: Gorilla, Human; Predicted Reactivity: Gibbon (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human NPFFR2. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except MFN2 (45%), MFN1 (45%).
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 522

• Applicable Applications for anti-NPFF2 antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (1 - 2 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic 20 amino acid peptide from N-terminal extracellular domain of human NPFFR2. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Gibbon (95%).
• Immunogen Type: Synthetic peptide
• Immunogen: NPFF2 / NPFFR2 antibody was raised against synthetic 20 amino acid peptide from N-terminal extracellular domain of human NPFFR2. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Gibbon (95%).
• Antigen Modification: N-Terminus
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-NPFFR2 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-NPFF2 antibody

The Neuropeptide FF 2 Receptor (NPFF2/HLWAR77/NPGPR) is a Neuropeptide Receptor GPCR. This receptor has high affinity for NPAF and NPFF, and is also weakly activated by FMRF-amide (Phe-Met-Arg-Phe-amide) and a variety of related peptides.

Product Categories/Family for anti-NPFF2 antibody

Family: GPCR; Subfamily: Neuropeptide

NCBI and Uniprot Product Information

• NCBI GI #: 221316654
• NCBI GeneID: 10886
• NCBI Accession #: NP_004876.2
• NCBI GenBank Nucleotide #: NM_004885.2
• UniProt Accession #: Q9Y5X5; Q96RV1; Q9NR49
• Molecular Weight: 15,055 Da
• NCBI Official Full Name: neuropeptide FF receptor 2 isoform 1
• NCBI Official Synonym Full Names: neuropeptide FF receptor 2
• NCBI Official Symbol: NPFFR2
• NCBI Official Synonym Symbols: GPR74; NPFF2; NPGPR; HLWAR77
• NCBI Protein Information: neuropeptide FF receptor 2; neuropeptide FF 2; G protein-coupled receptor 74; G-protein coupled receptor 74; G-protein coupled receptor HLWAR77; neuropeptide G-protein coupled receptor
• UniProt Protein Name: Neuropeptide FF receptor 2
• UniProt Gene Name: NPFFR2
• UniProt Synonym Gene Names: GPR74; NPFF2; NPGPR
• UniProt Entry Name: NPFF2_HUMAN

NCBI Description

This gene encodes a member of a subfamily of G-protein-coupled neuropeptide receptors. This protein is activated by the neuropeptides A-18-amide (NPAF) and F-8-amide (NPFF) and may function in pain modulation and regulation of the opioid system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]

Uniprot Description

NPFFR2: Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: integral to plasma membrane; plasma membrane; actin cytoskeleton

Molecular Function: G-protein coupled receptor activity; opioid receptor binding; neuropeptide receptor activity; peptide binding

Biological Process: regulation of adenylate cyclase activity; synaptic transmission; G-protein coupled receptor protein signaling pathway; neuropeptide signaling pathway; regulation of MAPKKK cascade; detection of abiotic stimulus; cellular response to hormone stimulus