Western Blot (WB)
((0. 03ug/ml) staining of Human Cerebellum lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)
Goat NOXA Polyclonal Antibody | anti-PMAIP1 antibody
Goat anti-NOXA Antibody
Western Blot: Approx 16kDa band observed in Human Brain (Cerebellum) lysates (calculated MW of 6. 03kDa according to NP_066950.1). The observed molecular weight corresponds to earlier findings with different antibodies from other commercial sources. Recommended concentration: 0. 03-0.1ug/ml.
Western Blot (WB)
((0. 03ug/ml) staining of Human Cerebellum lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)
Western Blot (WB)
((0. 03ug/ml) staining of Human Cerebellum lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)
NCBI and Uniprot Product Information
Uniprot Description
NOXA: Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1. Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1. Interacts with MCL1, BCL2A1 and BAX. Up-regulated by p53/TP53, phorbol esters, double- stranded RNA, IFNB1/IFN-beta and viruses. Highly expressed in adult T-cell leukemia cell line. Belongs to the PMAIP1 family.
Protein type: Mitochondrial; Apoptosis
Chromosomal Location of Human Ortholog: 18q21.32
Cellular Component: cytosol; mitochondrial outer membrane; mitochondrion; nucleus
Molecular Function: protein binding
Biological Process: apoptosis; caspase activation; cellular response to glucose starvation; defense response to virus; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; negative regulation of fibroblast proliferation; positive regulation of apoptosis; positive regulation of caspase activity; positive regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of neuron apoptosis; positive regulation of protein oligomerization; proteasomal protein catabolic process; protein insertion into mitochondrial membrane during induction of apoptosis; regulation of apoptosis; regulation of mitochondrial membrane permeability; release of cytochrome c from mitochondria; response to dsRNA; response to UV; response to X-ray; T cell homeostasis
Research Articles on PMAIP1
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Product Notes
The PMAIP1 pmaip1 (Catalog #AAA421772) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti-NOXA Antibody reacts with Tested: Human; Expected from sequence similarity: Human and may cross-react with other species as described in the data sheet. AAA Biotech's NOXA can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA), Western Blot (WB). Peptide ELISA: Antibody detection limit dilution 1: 16000. Western Blot: Approx 16kDa band observed in Human Brain (Cerebellum) lysates (calculated MW of 6. 03kDa according to NP_066950.1). The observed molecular weight corresponds to earlier findings with different antibodies from other commercial sources. Recommended concentration: 0. 03-0.1ug/ml. Researchers should empirically determine the suitability of the PMAIP1 pmaip1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: TQLRRFGDKL NFRQK. It is sometimes possible for the material contained within the vial of "NOXA, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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