Testing Data
Rabbit anti-Human NNMT Polyclonal Antibody | anti-NNMT antibody
NNMT Antibody
Reactivity
Human
Applications
Western Blot
Purity
Affinity Purified Antibody
Synonyms
NNMT; Polyclonal Antibody; NNMT Antibody; Nicotinamide N-methyltransferase; anti-NNMT antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Affinity Purified Antibody
Form/Format
100 ug (0.5 mg/ml) of antibody in PBS pH 7.2 containing 0.01 % BSA, 0.01 % thimerosal, and 50 % glycerol.
Appearance: Colorless liquid
Appearance: Colorless liquid
Concentration
0.5 mg/ml (varies by lot)
Sequence Length
264
Applicable Applications for anti-NNMT antibody
Western Blot (WB)
Application Notes
Western blot: 1-4 ug/ml.
Immunogen
Recombinant protein of human Nicotinamide N-Methyltransferase
Positive Control
Western Blot: Recombinant protein
Handling
The antibody solution should be gently mixed before use.
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Shelf Life: 12 months
Testing Data
Testing Data
Related Product Information for anti-NNMT antibody
Polyclonal Antibody to detect NNMT in human samples
Background: N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. NNMT is an important cytosolic methyltransferase catalyzing the N-methylation of nicotinamide, pyridines and structural analogs, playing a crucial role in the biotransformation and detoxification of many xenobiotic compounds. In the N-methylation process, NNMT uses S-adenosyl methionine as the methyl donor and nicotinamide as methyl acceptor. NNMT is mostly expressed in the liver, and a lower expression is seen in the kidney, lung, skeletal muscle, placenta and heart. It may also play an important role in regulating biological processes related to N-methyl nicotinamide such as anti-inflammatory, anti-thrombotic, vasoprotective, and gastroprotective properties. Increased NNMT activity was reported in many kinds of tumors. NNMT is a potential biomarker and therapeutic target in cancer identification and treatment. NNMT serum levels have significance in the premature detection and in the management of patients with colorectal cancer.
Background: N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. NNMT is an important cytosolic methyltransferase catalyzing the N-methylation of nicotinamide, pyridines and structural analogs, playing a crucial role in the biotransformation and detoxification of many xenobiotic compounds. In the N-methylation process, NNMT uses S-adenosyl methionine as the methyl donor and nicotinamide as methyl acceptor. NNMT is mostly expressed in the liver, and a lower expression is seen in the kidney, lung, skeletal muscle, placenta and heart. It may also play an important role in regulating biological processes related to N-methyl nicotinamide such as anti-inflammatory, anti-thrombotic, vasoprotective, and gastroprotective properties. Increased NNMT activity was reported in many kinds of tumors. NNMT is a potential biomarker and therapeutic target in cancer identification and treatment. NNMT serum levels have significance in the premature detection and in the management of patients with colorectal cancer.
Product Categories/Family for anti-NNMT antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
29,574 Da
NCBI Official Full Name
nicotinamide N-methyltransferase
NCBI Official Synonym Full Names
nicotinamide N-methyltransferase
NCBI Official Symbol
NNMT
NCBI Protein Information
nicotinamide N-methyltransferase
UniProt Protein Name
Nicotinamide N-methyltransferase
UniProt Gene Name
NNMT
UniProt Entry Name
NNMT_HUMAN
NCBI Description
N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor. [provided by RefSeq, Jul 2008]
Uniprot Description
NNMT: Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds. Belongs to the NNMT/PNMT/TEMT family.
Protein type: Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; EC 2.1.1.1; Methyltransferase
Chromosomal Location of Human Ortholog: 11q23.1
Cellular Component: cytosol
Molecular Function: nicotinamide N-methyltransferase activity
Biological Process: response to drug; methylation; organ regeneration; xenobiotic metabolic process; response to organic nitrogen
Research Articles on NNMT
Similar Products
Product Notes
The NNMT nnmt (Catalog #AAA841231) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The NNMT Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's NNMT can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western blot: 1-4 ug/ml. Researchers should empirically determine the suitability of the NNMT nnmt for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NNMT, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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