Rabbit NMDAR NR2B Polyclonal Antibody | anti-NMDA antibody
RABBIT ANTI RAT NMDA RECEPTOR NR2B
Purified IgG - lyophilised
Preparation
Buffer Solution
Shelf Life: 12 months from date of reconstitution.
NCBI and Uniprot Product Information
NCBI Description
subunit of the NMDA receptor glutamate gated ion channel; displays voltage dependent sensitivity to magnesium, calcium permeability, and glycine regulated activity; may facilitate learning and long term potentiation [RGD, Feb 2006]
Uniprot Description
NMDAR2B: an NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. Mediates neuronal functions in glutamate neurotransmission. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death.
Protein type: Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass
Cellular Component: presynaptic membrane; postsynaptic membrane; synaptic vesicle; neuron projection; cell surface; membrane; postsynaptic density; dendritic spine; terminal button; synapse; cell junction; Z disc; N-methyl-D-aspartate selective glutamate receptor complex
Molecular Function: neurotransmitter binding; interleukin-1 receptor binding; zinc ion binding; calcium channel activity; beta-catenin binding; drug binding; ionotropic glutamate receptor binding; protein binding; extracellular-glutamate-gated ion channel activity; protein heterodimerization activity; ionotropic glutamate receptor activity; glycine binding; N-methyl-D-aspartate selective glutamate receptor activity; cation channel activity; cell adhesion molecule binding; D2 dopamine receptor binding; receptor binding
Biological Process: regulation of long-term neuronal synaptic plasticity; fear response; startle response; behavioral fear response; response to toxin; positive regulation of glutamate secretion; rhythmic process; regulation of synaptic plasticity; response to other organism; receptor clustering; response to organic cyclic substance; response to carbohydrate stimulus; positive regulation of synaptic transmission; synaptic transmission; response to magnesium ion; behavioral response to pain; learning and/or memory; calcium ion transport; response to methylmercury; response to electrical stimulus; cation transport; associative learning; cellular response to magnesium starvation; synaptic transmission, glutamatergic; regulation of action potential; in utero embryonic development; hippocampus development; response to amphetamine; learning; response to cocaine; memory; response to manganese ion; detection of mechanical stimulus involved in sensory perception of pain; regulation of postsynaptic membrane potential; sensory organ development; response to ethanol; long-term memory; suckling behavior; response to mechanical stimulus; ionotropic glutamate receptor signaling pathway; response to cytokine stimulus; regulation of MAPKKK cascade; cerebral cortex development; response to calcium ion; regulation of excitatory postsynaptic membrane potential; multicellular organismal response to stress; response to amine stimulus
Research Articles on NMDA
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Product Notes
The NMDA grin2b (Catalog #AAA221030) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The RABBIT ANTI RAT NMDA RECEPTOR NR2B reacts with Fish, Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's NMDAR NR2B can be used in a range of immunoassay formats including, but not limited to, Immunohistology Frozen, Immunoprecipitation (IP), Western Blot (WB). Immunohistology - Frozen: Minimum Dilution: 1/1000; Maximum Dilution: 1/2000. Researchers should empirically determine the suitability of the NMDA grin2b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NMDAR NR2B, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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