Rabbit NLRP2 / NBS1 Polyclonal Antibody | anti-NLRP2 antibody

Rabbit Polyclonal to Human NLRP2 / NBS1

Cat. Num. AAA240396

• Gene Names: NLRP2; NBS1; PAN1; NALP2; PYPAF2; CLR19.9
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Western Blot
• Purity: Purified IgG
• Synonyms: NLRP2 / NBS1; Polyclonal Antibody; Rabbit Polyclonal to Human NLRP2 / NBS1; Anti-NLRP2 / NBS1 Antibody (C-Terminus) IHC-plus; NLRP2; CLR19.9; PAN1; NALP2; NBS1; PYPAF2; Human NLRP2; anti-NLRP2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: peptide corresponding to 12 amino acids near the carboxy-terminus of human NALP2
• Purity/Purification: Purified IgG
• Form/Format: PBS, 0.02% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 1062

• Applicable Applications for anti-NLRP2 antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
• Application Notes: IHC-P (5 ug/ml), WB (1 - 2 ug/ml); Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...
• Target Species: Human
• Immunogen Description: Synthetic peptide from human NLRP2 / NALP2.
• Immunogen Type: Synthetic peptide
• Immunogen: NLRP2 / NBS1 antibody was raised against synthetic peptide from human NLRP2 / NALP2.
• Antigen Modification: C-Terminus
• Preparation and Storage: Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.

Immunohistochemistry (IHC)

(Anti-NALP2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Western Blot (WB)

(Western blot of NALP2 in PC-3 cell lysate with NALP2 antibody at (A) 1 and (B) 2 ug/ml.)

Related Product Information for anti-NLRP2 antibody

NACHT, LRR and PYD Domains-containing Protein 2 (NLRP2) is a NLP protein, characterized by an N-terminal pyrin domain (PYD). NALP proteins are involved in the activation of caspase-1 (CASP1) by Toll-like receptors. They may also be involved in protein complexes that activate proinflammatory caspases.

NCBI and Uniprot Product Information

• NCBI GI #: 8923473
• NCBI GeneID: 55655
• NCBI Accession #: NP_060322.1
• NCBI GenBank Nucleotide #: NM_017852.3
• UniProt Accession #: Q9NX02; Q53FL5; Q59G09; Q8IXT0; Q9BVN5; Q9H6G6; Q9HAV9; Q9NWK3; B4DZL7; I3L0G4
• Molecular Weight: 117,883 Da
• NCBI Official Full Name: NACHT, LRR and PYD domains-containing protein 2 isoform 1
• NCBI Official Synonym Full Names: NLR family, pyrin domain containing 2
• NCBI Official Symbol: NLRP2
• NCBI Official Synonym Symbols: NBS1; PAN1; NALP2; PYPAF2; CLR19.9
• NCBI Protein Information: NACHT, LRR and PYD domains-containing protein 2; nucleotide-binding site protein 1; PYRIN-containing APAF1-like protein 2; NACHT, LRR and PYD containing protein 2; NACHT, leucine rich repeat and PYD containing 2; PYRIN domain and NACHT domain-containing protein 1; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 2
• UniProt Protein Name: NACHT, LRR and PYD domains-containing protein 2
• Protein Family: NACHT, LRR and PYD domains-containing protein
• UniProt Gene Name: NLRP2
• UniProt Synonym Gene Names: NALP2; NBS1; PAN1; PYPAF2
• UniProt Entry Name: NALP2_HUMAN

NCBI Description

NALP proteins, such as NALP2, are characterized by an N-terminal pyrin (MIM 608107) domain (PYD) and are involved in the activation of caspase-1 (CASP1; MIM 147678) by Toll-like receptors (see TLR4; MIM 603030). They may also be involved in protein complexes that activate proinflammatory caspases (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008]

Uniprot Description

NLRP2: Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases. Belongs to the NLRP family. 4 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 19q13.42

Cellular Component: cytoplasm

Molecular Function: protein binding; Pyrin domain binding; ATP binding

Biological Process: positive regulation of caspase activity; positive regulation of interleukin-1 beta secretion