Rabbit anti-Human NLRP10 Polyclonal Antibody | anti-NLRP10 antibody

NLRP10, CT (NLRP10, NALP10, NOD8, PYNOD, NACHT, LRR and PYD domains-containing protein 10, Nucleotide-binding oligomerization domain protein 8) (AP)

Cat. Num. AAA6325752

• Gene Names: NLRP10; NOD8; PAN5; PYNOD; NALP10; CLR11.1
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: NLRP10; Polyclonal Antibody; CT (NLRP10; NALP10; NOD8; PYNOD; NACHT; LRR and PYD domains-containing protein 10; Nucleotide-binding oligomerization domain protein 8) (AP); Nucleotide-binding oligomerization domain protein 8; anti-NLRP10 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).

• Applicable Applications for anti-NLRP10 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: NLRP10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 465-494 amino acids from the C-terminal region of human NLRP10.
• Conjugate: AP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(NLRP10 Antibody (C-term) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the NLRP10 antibody detected the NLRP10 protein (arrow).)

Related Product Information for anti-NLRP10 antibody

Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis. [provided by RefSeq].

Product Categories/Family for anti-NLRP10 antibody

Antibodies; Binding Proteins

References

Cummings, J.R., et al. Tissue Antigens 76(1):48-56(2010). Imamura, R., et al. J. Immunol. 184(10):5874-5884(2010). Ha, H.J., et al. Biochem. Genet. 47 (9-10), 665-670 (2009): Kinoshita, T., et al. J. Biol. Chem. 280(23):21720-21725(2005). Wang, Y., et al. Int. Immunol. 16(6):777-786(2004).

NCBI and Uniprot Product Information

• NCBI GI #: 28827807
• NCBI GeneID: 338322
• NCBI Accession #: NP_789791.1
• NCBI GenBank Nucleotide #: NM_176821.3
• UniProt Accession #: Q86W26; Q2M3C4; Q6JGT0
• Molecular Weight: 75,032 Da
• NCBI Official Full Name: NACHT, LRR and PYD domains-containing protein 10
• NCBI Official Synonym Full Names: NLR family, pyrin domain containing 10
• NCBI Official Symbol: NLRP10
• NCBI Official Synonym Symbols: NOD8; PAN5; PYNOD; NALP10; CLR11.1
• NCBI Protein Information: NACHT, LRR and PYD domains-containing protein 10; NACHT, leucine rich repeat and PYD containing 10; nucleotide-binding oligomerization domain protein 8; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 10
• UniProt Protein Name: NACHT, LRR and PYD domains-containing protein 10
• Protein Family: NACHT, LRR and PYD domains-containing protein
• UniProt Gene Name: NLRP10
• UniProt Synonym Gene Names: NALP10; NOD8; PYNOD
• UniProt Entry Name: NAL10_HUMAN

NCBI Description

Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis. [provided by RefSeq, Jul 2008]

Uniprot Description

NALP10: Inhibits CASP1/caspase-1-dependent IL1B secretion and PYCARD-mediated apoptosis, but not that induced by FAS or BID. Belongs to the NLRP family.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 11p15.4

Cellular Component: extrinsic to plasma membrane; cytoplasm

Molecular Function: ATP binding

Biological Process: positive regulation of T-helper 1 type immune response; innate immune response; defense response to Gram-negative bacterium; defense response to fungus