Western Blot (WB)
(Western blot analysis of NKRF antibody (Center) in Jurkat cell line lysates (35ug/lane). NKRF (arrow) was detected using the purified Pab.)
Rabbit anti-Human NKRF Polyclonal Antibody | anti-NKRF antibody
NKRF, ID (NF-kappa-B-repressing Factor, NFkB-repressing Factor, Transcription Factor NRF, ITBA4 Protein, NRF, ITBA4) (MaxLight 750)
FLISA: 1:1,000
Applications are based on unconjugated antibody.
Western Blot (WB)
(Western blot analysis of NKRF antibody (Center) in Jurkat cell line lysates (35ug/lane). NKRF (arrow) was detected using the purified Pab.)
Western Blot (WB)
(Western blot analysis of NKRF antibody (Center) in Jurkat cell line lysates (35ug/lane). NKRF (arrow) was detected using the purified Pab.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human brain reacted with NKRF Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human brain reacted with NKRF Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a transcriptional repressor that interacts with specific negative regulatory elements to mediate transcriptional repression of certain nuclear factor kappa B responsive genes. The protein localizes predominantly to the nucleolus with a small fraction found in the nucleoplasm and cytoplasm. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Uniprot Description
NKRF: Interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity. Also involved in the regulation of IL-8 transcription.
Protein type: RNA-binding; Transcription, coactivator/corepressor; Nucleolus
Chromosomal Location of Human Ortholog: Xq24
Cellular Component: endoplasmic reticulum; nucleolus; nucleus
Molecular Function: protein binding; DNA binding
Biological Process: transcription, DNA-dependent; negative regulation of transcription, DNA-dependent
Research Articles on NKRF
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Product Notes
The NKRF nkrf (Catalog #AAA6489954) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The NKRF, ID (NF-kappa-B-repressing Factor, NFkB-repressing Factor, Transcription Factor NRF, ITBA4 Protein, NRF, ITBA4) (MaxLight 750) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's NKRF can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), FLISA. WB: 1:50-1:100 FLISA: 1:1,000 Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the NKRF nkrf for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NKRF, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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