Rabbit Nitric Oxide Synthase, Endothelial (eNOS) (a.a. 2-11) Polyclonal Antibody | anti-NOS3 antibody
Rabbit anti eNOS
Recognizes Human Endothelial Nitric Oxide Synthase (eNOS). Specific for the amino terminal of eNOS. It recognizes the non-myrisylated form best, but does cross-react ~50% with the myristylated form
Reconstitute with 0.1ml PBS containing 10mg/ml BSA or with additional buffer for more dilute antibody.
NCBI and Uniprot Product Information
NCBI Description
Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Uniprot Description
Function: Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.
Catalytic activity: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+.
Cofactor: Heme group.Binds 1 FAD.Binds 1 FMN.Tetrahydrobiopterin (BH4). May stabilize the dimeric form of the enzyme.
Enzyme regulation: Stimulated by calcium/calmodulin. Inhibited by NOSIP and NOSTRIN. Ref.19 Ref.20
Subunit structure: Homodimer. Interacts with NOSIP and NOSTRIN. Ref.19 Ref.20
Subcellular location: Cell membrane. Membrane › caveola. Cytoplasm › cytoskeleton. Golgi apparatus. Note: Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle; which is favored by interaction with NOSIP and results in a reduced enzymatic activity. Ref.19 Ref.20 Ref.21 Ref.22
Tissue specificity: Platelets, placenta, liver and kidney. Ref.18
Polymorphism: Variation in NOS3 seem to be associated with susceptibility to coronary spasm.
Sequence similarities: Belongs to the NOS family.Contains 1 FAD-binding FR-type domain.Contains 1 flavodoxin-like domain.
Research Articles on NOS3
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Product Notes
The NOS3 nos3 (Catalog #AAA316207) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Nitric Oxide Synthase, Endothelial (eNOS) (a.a. 2-11), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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