Rabbit NIPSNAP Polyclonal Antibody | anti-NIPSNAP antibody

NIPSNAP Antibody

Cat. Num. AAA9413203

• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity chromatography purified via peptide column
• Synonyms: NIPSNAP; Polyclonal Antibody; NIPSNAP Antibody; Non-neuronal SNAP25-like protein; NIPSNAP1; anti-NIPSNAP antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Purity/Purification: Affinity chromatography purified via peptide column
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 284

• Applicable Applications for anti-NIPSNAP antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen Type: Peptide
• Immunogen Description: Raised against a 18 amino acid peptide from near the carboxy terminus of human NIPSNAP.
• Target Name: NIPSNAP
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of NIPSNAP in human brain tissue lysate with NIPSNAP antibody at (A) 0.5 and (B) 1 ug/mL.)

Immunohistochemistry (IHC)

(Immunohistochemical staining of human brain tissue using Nipsnap antibody at 2.5 ug/mL.)

Related Product Information for anti-NIPSNAP antibody

NIPSNAP is a member of an evolutionarily well conserved gene family and has a strong sequence similarity to the central portion of a protein encoded by C. elegans chromosome III between a 4-nitrophenylphosphatase (NIP) domain and non-neuronal SNAP25-like protein. Recent studies have indicated that NIPSNAP is involved in the regulation of the Ca2+-selective transient receptor potential vanilloid channel 6 (TRPV6). NIPSNAP1 associates with TRPV6 at the plasma membrane and inhibits TRPV6 currents. Other studies show that NIPSNAP's expression is reduced in the phenylketonuria (PKU) mouse brain, suggesting that NIPSNAP may play a role in memory.

Product Categories/Family for anti-NIPSNAP antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 193211616
• NCBI GeneID: 8508
• NCBI Accession #: NP_003625
• NCBI GenBank Nucleotide #: NM_003634.3
• Molecular Weight: 33,310 Da
• NCBI Official Full Name: protein NipSnap homolog 1 isoform 1
• NCBI Official Synonym Full Names: nipsnap homolog 1 (C. elegans)
• NCBI Official Symbol: NIPSNAP1
• NCBI Protein Information: protein NipSnap homolog 1
• UniProt Protein Name: Protein NipSnap homolog 1
• Protein Family: Protein
• UniProt Gene Name: NIPSNAP1
• UniProt Synonym Gene Names: NipSnap1
• UniProt Entry Name: NIPS1_HUMAN

NCBI Description

This gene encodes a member of the NipSnap family of proteins that may be involved in vesicular transport. A similar protein in mice inhibits the calcium channel TRPV6, and is also localized to the inner mitochondrial membrane where it may play a role in mitochondrial DNA maintenance. A pseudogene of this gene is located on the short arm of chromosome 17. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]

Uniprot Description

NIPSNAP1: a member of the NipSnap family of proteins that may be involved in vesicular transport. A similar protein in mice inhibits the calcium channel TRPV6, and is also localized to the inner mitochondrial membrane where it may play a role in mitochondrial DNA maintenance. A pseudogene of this gene is located on the short arm of chromosome 17. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]

Protein type: Mitochondrial

Chromosomal Location of Human Ortholog: 22q12.2

Cellular Component: mitochondrion; mitochondrial inner membrane

Molecular Function: neurotransmitter binding

Biological Process: sensory perception of pain