Immunohistochemistry (IHC)
(The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using NIPA1 Antibody at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200))
Rabbit anti-Human NIPA1 Polyclonal Antibody | anti-NIPA1 antibody
NIPA1 Antibody
Immunohistochemistry (IHC)
(The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using NIPA1 Antibody at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200))
Immunohistochemistry (IHC)
(The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using NIPA1 Antibody at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200))
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a magnesium transporter that associates with early endosomes and the cell surface in a variety of neuronal and epithelial cells. This protein may play a role in nervous system development and maintenance. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with autosomal dominant spastic paraplegia 6. [provided by RefSeq, Nov 2008]
Uniprot Description
NIPA1: Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+). Defects in NIPA1 are the cause of spastic paraplegia autosomal dominant type 6 (SPG6). Spastic paraplegia is a degenerative spinal cord disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Belongs to the NIPA family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 15q11.2
Cellular Component: membrane; plasma membrane
Molecular Function: magnesium ion transmembrane transporter activity
Biological Process: magnesium ion transport; transmembrane transport
Disease: Spastic Paraplegia 6, Autosomal Dominant
Research Articles on NIPA1
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Product Notes
The NIPA1 nipa1 (Catalog #AAA9417305) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The NIPA1 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's NIPA1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). Immunohistochemistry: 1: 20-100. Researchers should empirically determine the suitability of the NIPA1 nipa1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NIPA1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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