Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Rabbit anti-Human Neurotrophic Tyrosine Kinase Receptor Type 3 Polyclonal Antibody | anti-NTRK3 antibody
Polyclonal Antibody to Neurotrophic Tyrosine Kinase Receptor Type 3 (NTRK3)
Immunohistochemistry: 5-20ug/mL;1:25-100
Immunocytochemistry: 5-20ug/mL;1:25-100
Optimal working dilutions must be determined by end user.
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Immunohistochemistry (IHC)
(DAB staining on fromalin fixed paraffin- embedded Kidney tissue))
Immunohistochemistry (IHC)
(DAB staining on fromalin fixed paraffin- embedded Kidney tissue))
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Uniprot Description
TrkC: a receptor tyrosine kinase of the TRK family. Receptor for neurotrophin-3 (NT-3). Known substrates for the trk receptors are SHC, PI-3 kinase, and PLCG1. Four alternatively spliced isoforms are known.
Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group; Trk family
Chromosomal Location of Human Ortholog: 15q25.3
Cellular Component: cytoplasm; integral component of plasma membrane; plasma membrane; receptor complex
Molecular Function: ATP binding; GPI-linked ephrin receptor activity; neurotrophin binding; neurotrophin receptor activity; p53 binding; protein binding
Biological Process: activation of MAPK activity; activation of protein kinase B activity; cellular response to retinoic acid; circadian rhythm; cochlea development; ephrin receptor signaling pathway; heart development; lens fiber cell differentiation; mechanoreceptor differentiation; modification by virus of host cell transcription; negative regulation of astrocyte differentiation; negative regulation of protein phosphorylation; neuron fate specification; neuron migration; neurotrophin signaling pathway; peptidyl-tyrosine phosphorylation; positive regulation of actin cytoskeleton reorganization; positive regulation of apoptosis; positive regulation of axon extension involved in regeneration; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of gene expression; positive regulation of peptidyl-serine phosphorylation; positive regulation of positive chemotaxis; positive regulation of protein phosphorylation; positive regulation of synaptogenesis; protein autophosphorylation; response to axon injury; response to corticosterone stimulus; response to ethanol; transmembrane receptor protein tyrosine kinase signaling pathway
Research Articles on NTRK3
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Product Notes
The NTRK3 ntrk3 (Catalog #AAA2027680) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Neurotrophic Tyrosine Kinase Receptor Type 3 (NTRK3) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Neurotrophic Tyrosine Kinase Receptor Type 3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA). Western blotting: 0.2-2ug/mL;1:250-2500 Immunohistochemistry: 5-20ug/mL;1:25-100 Immunocytochemistry: 5-20ug/mL;1:25-100 Optimal working dilutions must be determined by end user. . Researchers should empirically determine the suitability of the NTRK3 ntrk3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Neurotrophic Tyrosine Kinase Receptor Type 3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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