Rabbit anti-Human Neuropeptide FF2 Receptor Polyclonal Antibody | anti-NPFFR2 antibody

Neuropeptide FF2 Receptor (NPFF2)

Cat. Num. AAA612035

• Gene Names: NPFFR2; GPR74; NPFF2; NPGPR; HLWAR77
• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Neuropeptide FF2 Receptor; Polyclonal Antibody; Neuropeptide FF2 Receptor (NPFF2); Anti -Neuropeptide FF2 Receptor (NPFF2); anti-NPFFR2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human Neuropeptide FF2 Receptor.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid.

• Applicable Applications for anti-NPFFR2 antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.
• Immunogen: N-terminus (MNEKWDTNSSENWHPI) and C-terminus (ELVMEELKETTNSSEI) of human NPFF2 protein
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-NPFFR2 antibody

The central nervous system neuropeptide FF (NPFF), is believed to play a role in pain modulation and opiate tolerance as well as other physiological functions. Two G protein-coupled receptors, NPFF1 and NPFF2, were isolated from the human central nervous system.

Product Categories/Family for anti-NPFFR2 antibody

Antibodies; Abs to Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 221316654
• NCBI GeneID: 10886
• NCBI Accession #: NP_004876.2
• NCBI GenBank Nucleotide #: NM_004885.2
• UniProt Accession #: Q9Y5X5; Q96RV1; Q9NR49
• Molecular Weight: 60,270 Da
• NCBI Official Full Name: neuropeptide FF receptor 2 isoform 1
• NCBI Official Synonym Full Names: neuropeptide FF receptor 2
• NCBI Official Symbol: NPFFR2
• NCBI Official Synonym Symbols: GPR74; NPFF2; NPGPR; HLWAR77
• NCBI Protein Information: neuropeptide FF receptor 2; neuropeptide FF 2; OTTHUMP00000160367; OTTHUMP00000160368; OTTHUMP00000160369; G protein-coupled receptor 74; G-protein coupled receptor 74; G-protein coupled receptor HLWAR77; neuropeptide G-protein coupled receptor
• UniProt Protein Name: Neuropeptide FF receptor 2
• Protein Family: Neuropeptide FF receptor
• UniProt Gene Name: NPFFR2
• UniProt Synonym Gene Names: GPR74; NPFF2; NPGPR
• UniProt Entry Name: NPFF2_HUMAN

NCBI Description

This gene encodes a member of a subfamily of G-protein-coupled neuropeptide receptors. This protein is activated by the neuropeptides A-18-amide (NPAF) and F-8-amide (NPFF) and may function in pain modulation and regulation of the opioid system. Alternative splicing results in multiple transcript variants. [provided by RefSeq]

Uniprot Description

NPFFR2: Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: integral to plasma membrane; plasma membrane; actin cytoskeleton

Molecular Function: G-protein coupled receptor activity; opioid receptor binding; neuropeptide receptor activity; peptide binding

Biological Process: regulation of adenylate cyclase activity; G-protein coupled receptor protein signaling pathway; synaptic transmission; neuropeptide signaling pathway; regulation of MAPKKK cascade; detection of abiotic stimulus; cellular response to hormone stimulus