Goat Neuroligin 2 Polyclonal Antibody | anti-NLGN2 antibody

Neuroligin 2 (NLGN2, KIAA1366)

Cat. Num. AAA620083

• Gene Names: NLGN2; KIAA1366
• Reactivity: Canine, Human, Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by affinity chromatography.
• Synonyms: Neuroligin 2; Polyclonal Antibody; Neuroligin 2 (NLGN2; KIAA1366); Anti -Neuroligin 2 (NLGN2; anti-NLGN2 antibody

• Host: Goat
• Reactivity: Canine, Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: Recognizes human Neuroligin 2. Species Crossreactivity: mouse, rat, canine.
• Purity/Purification: Affinity Purified; Purified by affinity chromatography.
• Form/Format: Supplied as a liquid in Tris saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.

• Applicable Applications for anti-NLGN2 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA, Western Blot.; Dilution: Peptide ELISA: 1:8,000.; Western Blot: 1-3ug/ml. Approx 90kD band observed in Human Pancreas lysates (calculated MW of 90.8kD according to NP_065846.1). Optimal dilutions to be determined by the researcher.
• Immunogen: A synthetic peptide from the C-terminus of aa--NPPDTDIRDPGKK
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Chemiluminescence

((2ug/ml) staining of Human Pancrease lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)

Product Categories/Family for anti-NLGN2 antibody

Antibodies; Abs to Neuroligins

NCBI and Uniprot Product Information

• NCBI GI #: 21309947
• NCBI GeneID: 57555
• UniProt Accession #: Q8NFZ4; Q9P2I1
• Molecular Weight: 90,820 Da
• NCBI Official Full Name: neuroligin 2
• NCBI Official Synonym Full Names: neuroligin 2
• NCBI Official Symbol: NLGN2
• NCBI Official Synonym Symbols: KIAA1366
• NCBI Protein Information: neuroligin-2; OTTHUMP00000135277
• UniProt Protein Name: Neuroligin-2
• Protein Family: Neuroligin
• UniProt Gene Name: NLGN2
• UniProt Synonym Gene Names: KIAA1366
• UniProt Entry Name: NLGN2_HUMAN

NCBI Description

This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. [provided by RefSeq]

Uniprot Description

NLGN2: Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma- aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion. Belongs to the type-B carboxylesterase/lipase family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: presynaptic membrane; extracellular space; postsynaptic membrane; cell surface; membrane; integral to plasma membrane; synapse; cell junction

Molecular Function: neurexin binding; cell adhesion molecule binding; receptor activity

Biological Process: regulation of synaptic transmission; positive regulation of synaptogenesis; cell-cell adhesion; synaptogenesis; metabolic process; synapse organization and biogenesis; positive regulation of synaptic transmission, GABAergic; neuron adhesion; neurological control of breathing; neuromuscular process controlling balance; sensory perception of pain; intercellular junction maintenance; positive regulation of synaptic transmission, glutamatergic