Rabbit anti-Rat NCX2 Polyclonal Antibody | anti-Slc8a2 antibody
NCX2 (Sodium Calcium Exchanger)
Gene Names
Slc8a2; Ncx2
Reactivity
Rat
Applications
ELISA, Western Blot
Purity
SerumSerum
Synonyms
NCX2; Polyclonal Antibody; NCX2 (Sodium Calcium Exchanger); Anti -NCX2 (Sodium Calcium Exchanger); anti-Slc8a2 antibody
Host
Rabbit
Reactivity
Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes rat NCX2. Species sequence homology: mouse; 100%, human; 81%
Purity/Purification
Serum
Serum
Serum
Form/Format
Supplied as a liquid in PBS, 0.05% sodium azide.
Applicable Applications for anti-Slc8a2 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes
Suitable for use in ELISA andWestern Blot.
Dilution: Western Blot: 1:1000-1:5000
ELISA: 1:10,000-1:50,000. Control peptide can be used to coat ELISA plates at 1ug/ml.
Dilution: Western Blot: 1:1000-1:5000
ELISA: 1:10,000-1:50,000. Control peptide can be used to coat ELISA plates at 1ug/ml.
Immunogen
A synthetic peptide corresponding to 22aa within the N-terminal cytoplasmic domain of rat NCX2 (KLH).
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Related Product Information for anti-Slc8a2 antibody
Ca2+ plays a critical role in intracellular signaling. Intracellular Ca2+ levels are tightly controlled by continuos removal of Ca2+ via ATP-driven Ca2+ pump in the endoplasmic reticulum and plasma membrane, and Ca2+ transport system, the Na+/Ca2+ exchangers (NCX), in the plasma membrane. NCX can move Ca2+ either into or out of cells, depending on the net Na+, Ca2+, and K+ gradient across the membrane. In most cells, 3 Na+ are exchanged for 1 Ca2+. In mammals, at least 5 distinct genes code for the exchangers: Three NCX (NCX1, NCX2, and NCX3), and two in the NCKX family (NCKX1 and NCKX2). NCX share significant sequence homology (~70%), display 11 TM domains, a large central, intracellular hydrophilic regulatory loop between TM5 and 6, extracellular N-terminus and cytoplasmic C-terminus. The N-terminal signal peptide is cleaved off from the mature exchanger protein. NCX1 (rat 971 aa, human 970 aa, mouse 970 aa) is most prominently expressed in the heart where it plays a major role in excitation-contraction coupling, but is also present in most other tissues. Alternative spicing of NCX1/NACA1 produces numerous tissue specific isoforms (heart NACA1; Kidney NACA2, -3, and -7; brain NACA4-6). NCX2 (rat 921 aa) is restricted to brain and skeletal muscle. NCX3 (rat 927 aa) shares 73-75% with NCX1 and NCX2. NCX3 is also restricted to brain and muscle.
Product Categories/Family for anti-Slc8a2 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
18,980 Da
NCBI Official Full Name
Na+/Ca2+ exchanger NCX2 isoform
NCBI Official Synonym Full Names
solute carrier family 8 (sodium/calcium exchanger), member 2
NCBI Official Symbol
Slc8a2
NCBI Official Synonym Symbols
Ncx2
NCBI Protein Information
sodium/calcium exchanger 2
UniProt Protein Name
Na+/Ca2+ exchanger NCX2 isoform
Protein Family
UniProt Gene Name
Slc8a2
UniProt Synonym Gene Names
NCX2
UniProt Entry Name
Q8R504_MOUSE
Uniprot Description
SLC8A2: Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores. Belongs to the sodium/potassium/calcium exchanger family. SLC8 subfamily.
Protein type: Transporter, SLC family; Transporter; Membrane protein, integral; Membrane protein, multi-pass
Cellular Component: microtubule; cell projection; cell soma; mitochondrion; dendritic spine; plasma membrane; cytosol
Molecular Function: calcium:sodium antiporter activity
Biological Process: sodium ion transport
Research Articles on Slc8a2
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Product Notes
The Slc8a2 slc8a2 (Catalog #AAA617013) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The NCX2 (Sodium Calcium Exchanger) reacts with Rat and may cross-react with other species as described in the data sheet. AAA Biotech's NCX2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in ELISA andWestern Blot. Dilution: Western Blot: 1:1000-1:5000 ELISA: 1:10,000-1:50,000. Control peptide can be used to coat ELISA plates at 1ug/ml. Researchers should empirically determine the suitability of the Slc8a2 slc8a2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NCX2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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