Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human skin cancer slide using MBS7611943(NCR1 Antibody) at dilution of 1:200)
Rabbit anti-Human, Mouse NCR1 Polyclonal Antibody | anti-NCR1 antibody
Anti-NCR1 antibody
Gene Names
NCR1; LY94; CD335; NKP46; NK-p46
Reactivity
Human, Mouse
Applications
ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
Purity
>=95% as determined by SDS-PAGE. Immunogen affinity purified
Synonyms
NCR1; Polyclonal Antibody; Anti-NCR1 antibody; CD335; LY94; NK-p46; NKP46; anti-NCR1 antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
>=95% as determined by SDS-PAGE. Immunogen affinity purified
Form/Format
Liquid. PBS with 0.02% sodium azide and 50% glycerol pH7.3
Applicable Applications for anti-NCR1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes
WB: 1:500-1:2000
IHC: 1:50-1:200
IF: 1:50-1:200
IHC: 1:50-1:200
IF: 1:50-1:200
Immunogen
Natural cytotoxicity triggering receptor 1
Preparation and Storage
Store at -20 degree C for 12 months. Avoid repeated freeze/thaw cycles.
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human skin cancer slide using MBS7611943(NCR1 Antibody) at dilution of 1:200)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human skin cancer slide using MBS7611943(NCR1 Antibody) at dilution of 1:200)
Western Blot (WB)
(A431 cells were subjected to SDS PAGE followed by western blot with MBS7611943(NCR1 Antibody) at dilution of 1:1000)
Western Blot (WB)
(A431 cells were subjected to SDS PAGE followed by western blot with MBS7611943(NCR1 Antibody) at dilution of 1:1000)
Related Product Information for anti-NCR1 antibody
The natural cytotoxicity receptors (NCRs) are a recently characterized family of Ig-like activation receptors that appear to be major triggering receptors in tumor cell recognition. NCR1 is a glycoprotein that has two extracellular Ig-like domains followed by a ~40 amino acid residue stalk region, a type I transmembrane domain, and a short cytoplasmic tail. NCR1 has been shown to represent a novel NK cell-specific molecule involved in human NK cell activation. NCR1 has been implicated in NK cell-mediated lysis of several autologous tumor cells and pathogen-infected cell lines.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
34,481 Da
NCBI Official Full Name
natural cytotoxicity triggering receptor 1 isoform b
NCBI Official Synonym Full Names
natural cytotoxicity triggering receptor 1
NCBI Official Symbol
NCR1
NCBI Official Synonym Symbols
LY94; CD335; NKP46; NK-p46
NCBI Protein Information
natural cytotoxicity triggering receptor 1; NK cell-activating receptor; natural killer cell p46-related protein; lymphocyte antigen 94 homolog (activating NK-receptor; NK-p46)
UniProt Protein Name
Natural cytotoxicity triggering receptor 1
Protein Family
UniProt Gene Name
NCR1
UniProt Synonym Gene Names
LY94; NK-p46; NKp46; hNKp46
UniProt Entry Name
NCTR1_HUMAN
Uniprot Description
NCR1: Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Belongs to the natural cytotoxicity receptor (NCR) family. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Apoptosis; Receptor, misc.
Chromosomal Location of Human Ortholog: 19q13.42
Cellular Component: SWI/SNF complex; integral to plasma membrane
Molecular Function: receptor signaling protein activity
Biological Process: regulation of natural killer cell mediated cytotoxicity; cellular defense response; natural killer cell activation; signal transduction
Research Articles on NCR1
Similar Products
Product Notes
The NCR1 ncr1 (Catalog #AAA7611943) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-NCR1 antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's NCR1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF). WB: 1:500-1:2000 IHC: 1:50-1:200 IF: 1:50-1:200. Researchers should empirically determine the suitability of the NCR1 ncr1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NCR1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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