Rabbit anti-Human NCDN Polyclonal Antibody | anti-NCDN antibody

NCDN, NT (NCDN, KIAA0607, Neurochondrin)

Cat. Num. AAA6005961

• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: NCDN; Polyclonal Antibody; NT (NCDN; KIAA0607; Neurochondrin); Anti -NCDN; anti-NCDN antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-NCDN antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in Western Blot, ELISA; Dilution: ELISA: 1:1,000; Western Blot: 1:100-500
• Immunogen: NCDN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 113-144 amino acids from the N-terminal region of human NCDN.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(NCDN Antibody (N-term) western blot analysis in Y79 cell line lysates (35ug/lane).This demonstrates the NCDN antibody detected the NCDN protein (arrow).)

Related Product Information for anti-NCDN antibody

This gene encodes a leucine-rich cytoplasmic protein, which is highly similar to a mouse protein that negatively regulates Ca/calmodulin-dependent protein kinase II phosphorylation and may be essential for spatial learning processes. Several alternatively spliced transcript variants of this gene have been described.

Product Categories/Family for anti-NCDN antibody

Antibodies; Abs to KIAA; orf

NCBI and Uniprot Product Information

• NCBI GI #: 62526031
• NCBI GeneID: 23154
• NCBI Accession #: NP_001014841.1
• NCBI GenBank Nucleotide #: NM_001014841.1
• UniProt Accession #: Q9UBB6; Q9UBY2; Q9Y4A6; Q9Y4D9; D3DPR9
• Molecular Weight: 78,864 Da
• NCBI Official Full Name: neurochondrin isoform 2
• NCBI Official Synonym Full Names: neurochondrin
• NCBI Official Symbol: NCDN
• NCBI Protein Information: neurochondrin
• UniProt Protein Name: Neurochondrin
• Protein Family: Neurochondrin
• UniProt Gene Name: NCDN
• UniProt Synonym Gene Names: KIAA0607
• UniProt Entry Name: NCDN_HUMAN

NCBI Description

This gene encodes a leucine-rich cytoplasmic protein, which is highly similar to a mouse protein that negatively regulates Ca/calmodulin-dependent protein kinase II phosphorylation and may be essential for spatial learning processes. Several alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jul 2008]

Uniprot Description

NCDN: Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling. Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin- concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth. Belongs to the neurochondrin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Inhibitor

Chromosomal Location of Human Ortholog: 1p34.3

Cellular Component: cell soma; membrane; axon; dendrite; nucleus; cytosol

Biological Process: neurite development; regulation of neuronal synaptic plasticity; bone resorption