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Testing Data (Fig: Western blot analysis on mouse kidney using anti-CD18 polyclonal antibody)

NCAM-L1 Polyclonal Antibody | anti-NCAM-L1 antibody

NCAM-L1 Antibody

Gene Names
L1CAM; S10; HSAS; MASA; MIC5; SPG1; CAML1; CD171; HSAS1; N-CAML1; NCAM-L1; N-CAM-L1
Reactivity
Mouse, Human, Rat
Applications
Western Blot, Immunocytochemistry
Purity
Affinity purified
Synonyms
NCAM-L1; Polyclonal Antibody; NCAM-L1 Antibody; anti-NCAM-L1 antibody
Ordering
For Research Use Only!
Reactivity
Mouse, Human, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to a region of CD-10.
Purity/Purification
Affinity purified
Form/Format
1*TBS (pH7.4), 0.5%BSA, 25% Glycerol.
Sequence Length
1257
Applicable Applications for anti-NCAM-L1 antibody
Western Blot (WB), Immunocytochemistry (ICC)
Application Notes
WB: 1:500
Preservative
0.05% Sodium Azide.
Cellular Localization
Cell Membrane
Positive Control
Fetal Brain
Preparation and Storage
Store at +4 degree C after thawing. Aliquot store at-20 degree C or-80 degree C. Avoid repeated freeze/thaw cycles.

Testing Data

(Fig: Western blot analysis on mouse kidney using anti-CD18 polyclonal antibody)

Testing Data (Fig: Western blot analysis on mouse kidney using anti-CD18 polyclonal antibody)
Related Product Information for anti-NCAM-L1 antibody
Neprilysin(CD10) is a zinc-dependent metalloprotease enzyme that degrades a number of small secreted peptides, most notably the amyloid beta peptide. peptides. Neprilysin is expressed on the cells of lymphoblastic, Burkitt's, and follicular germinal center lymphomas, immature B cells with in adult bone marrow and on cells from patients with chronic myelocytic leukemia (CML). In neurons, neprilysin is regulated by the protein nicastrin, a component of the gamma secretase complex that performs a necessary step in processing amyloid precursor protein to amyloid.
References
1.Malfroy B., Kuang W.-J., Seeburg P.H., Mason A.J., Schofield P.R.; "Molecular cloning and amino acid sequence of human enkephalinase (neutral endopeptidase)."; FEBS Lett. 229:206-210(1988). 2.Turner AJ, Isaac RE, Coates D, et al. The neprilysin (NEP) family of zinc metalloendopeptidases: genomics and function [J]. Bioessays, 2001, 23:261-269. 3.Oefner C, D'Arcy A, Hennig M, et al. Structure of Human Neutral Endopeptidase (Neprilysin) Complexed with Phosphoramidon [J]. J Mol Biol, 2000, 296:341-349.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
~220kDa
NCBI Official Full Name
neural cell adhesion molecule L1 isoform 1
NCBI Official Synonym Full Names
L1 cell adhesion molecule
NCBI Official Symbol
L1CAM
NCBI Official Synonym Symbols
S10; HSAS; MASA; MIC5; SPG1; CAML1; CD171; HSAS1; N-CAML1; NCAM-L1; N-CAM-L1
NCBI Protein Information
neural cell adhesion molecule L1
UniProt Protein Name
Neural cell adhesion molecule L1
UniProt Gene Name
L1CAM
UniProt Synonym Gene Names
CAML1; MIC5; N-CAM-L1; NCAM-L1

NCBI Description

The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause X-linked neurological syndromes known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of this gene results in multiple transcript variants, some of which include an alternate exon that is considered to be specific to neurons. [provided by RefSeq, May 2013]

Uniprot Description

Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity.

Research Articles on NCAM-L1

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Product Notes

The NCAM-L1 l1cam (Catalog #AAA857663) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The NCAM-L1 Antibody reacts with Mouse, Human, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's NCAM-L1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC). WB: 1:500. Researchers should empirically determine the suitability of the NCAM-L1 l1cam for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NCAM-L1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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