Rabbit anti-Human NBC2 Polyclonal Antibody | anti-Slc4a7 antibody
NBC2 (HCO3 Cotransporters 2)
Gene Names
Slc4a7; NBC3; NBCn1
Reactivity
Human
Applications
ELISA, Western Blot
Purity
Affinity PurifiedPurified by immunoaffinity chromatography.
Synonyms
NBC2; Polyclonal Antibody; NBC2 (HCO3 Cotransporters 2); Anti -NBC2 (HCO3 Cotransporters 2); anti-Slc4a7 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes human NBC2. No significant sequence homology was found with NBC1 or NBC3. Species sequence homology: rat-100%.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Purified by immunoaffinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.1% BSA, before the addition of glycerol to 40%.
Applicable Applications for anti-Slc4a7 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes
Suitable for use in ELISA and Western Blot.
Dilution: Western Blot: 1-10ug/ml using Chemiluminescence technique.
ELISA: 1:5000-1:50,000 using 50-100ng of control peptide/well.
Dilution: Western Blot: 1-10ug/ml using Chemiluminescence technique.
ELISA: 1:5000-1:50,000 using 50-100ng of control peptide/well.
Immunogen
A 20aa peptide sequence within the cytoplasmic, C-terminus of human NBC2 (KLH).
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for anti-Slc4a7 antibody
Bicarbonate, along with CO2, is the major pH buffer of biological fluids. A great majority of HCO3- reabsorption occurs via trans-cellular coupling of the luminal Na-H+ exchanger 3 and Na+-H+ ATPase with the basolateral Na+ HCO3- cotransporters (NBC). Several related proteins constitute the emerging NBC family (NBC1-3) of membrane cotransporters that are found in a variety of epithelial and non-epithelial tissues, and may be tissue specific. Physiologically, NBC is electrogenic, Na+ and HCO3- dependent, Cl- independent, and inhibited by stilbenes (DIDS and SITS). The NBC family of proteins are 30-35% related to anion exchangers (AE2 and AE3; SLC4A1- SLC4A3) and display the same protein topology: (a) At least 10 TM domains with both the N and C-termini predicted to be intracellular, (b) presence of a large, glycosylated, extracellular loop between TM5 and TM6; and (c) the lysine residues are conserved at predicted DIDS-reactive sites.
Product Categories/Family for anti-Slc4a7 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
135,954 Da
NCBI Official Full Name
NBC-like protein 2
NCBI Official Synonym Full Names
solute carrier family 4, sodium bicarbonate cotransporter, member 7
NCBI Official Symbol
Slc4a7
NCBI Official Synonym Symbols
NBC3; NBCn1
NCBI Protein Information
sodium bicarbonate cotransporter 3; NBC-like protein; solute carrier family 4 member 7; electroneutral sodium bicarbonate cotransporter 1
UniProt Protein Name
Sodium bicarbonate cotransporter 3
Protein Family
UniProt Gene Name
Slc4a7
UniProt Synonym Gene Names
Nbc; Nbc2; Nbc3; Nbcn1
UniProt Entry Name
S4A7_RAT
NCBI Description
regulates intracellular pH in different cells along with Na+-driven HCO3- transporters, the Na+-driven Cl-/HCO3- exchanger [RGD]
Uniprot Description
SLC4A7: Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Regulates intracellular pH and may play a role in bicarbonate salvage in secretory epithelia. May also have an associated sodium channel activity. Belongs to the anion exchanger (TC 2.A.31) family. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter, SLC family; Membrane protein, integral; Transporter; Membrane protein, multi-pass
Cellular Component: stereocilium; integral to plasma membrane; basolateral plasma membrane; cytoplasm; apical plasma membrane; plasma membrane; integral to membrane; synapse; cytoplasmic vesicle
Molecular Function: inorganic anion exchanger activity; sodium:bicarbonate symporter activity
Biological Process: cochlear nucleus development; visual perception; bicarbonate transport; regulation of intracellular pH; auditory receptor cell development; retinal cell programmed cell death
Research Articles on Slc4a7
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Product Notes
The Slc4a7 slc4a7 (Catalog #AAA611906) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The NBC2 (HCO3 Cotransporters 2) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's NBC2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in ELISA and Western Blot. Dilution: Western Blot: 1-10ug/ml using Chemiluminescence technique. ELISA: 1:5000-1:50,000 using 50-100ng of control peptide/well. Researchers should empirically determine the suitability of the Slc4a7 slc4a7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NBC2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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