Rabbit anti-Human NAT8 Polyclonal Antibody | anti-NAT8 antibody

NAT8 Antibody, Biotin conjugated

Cat. Num. AAA1494080

• Gene Names: NAT8; GLA; CML1; CCNAT; Hcml1; ATase2; TSC501; TSC510
• Reactivity: Human
• Applications: ELISA
• Purity: >95%, Protein G Purified
• Synonyms: NAT8; Polyclonal Antibody; NAT8 Antibody; Biotin conjugated; N-acetyltransferase 8 (EC:2.3.1.-); Acetyltransferase 2; ATase2; Camello-like protein 1; Cysteinyl-conjugate N-acetyltransferase (EC:2.3.1.80); CCNAT; anti-NAT8 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%, Protein G Purified
• Sequence Length: 227

• Applicable Applications for anti-NAT8 antibody: ELISA (EIA)
• Storage Buffer: Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Conjugate: Biotin
• Immunogen: Recombinant human N-acetyltransferase 8 protein
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-139400
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Related Product Information for anti-NAT8 antibody

Acetylates the free alpha-amino group of cysteine S-conjugates to form mercapturic acids (PubMed:20392701). This is the final step in a major route for detoxification of a wide variety of reactive electrophiles which starts with their incorporation into glutathione S-conjugates. The glutathione S-conjugates are then further processed into cysteine S-conjugates and finally mercapturic acids which are water soluble and can be readily excreted in urine or bile. Alternatively, may have a lysine N-acetyltransferase activity catalyzing peptidyl-lysine N6-acetylation of various proteins. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1 (PubMed:24556617). May also regulate amyloid beta-peptide secretion through acetylation of BACE1 and the regulation of its expression in neurons (PubMed:19011241).

NCBI and Uniprot Product Information

• NCBI GI #: 117190517
• NCBI GeneID: 9027
• NCBI Accession #: NP_003951.3
• NCBI GenBank Nucleotide #: NM_003960.3
• UniProt Accession #: Q9UHE5; O75839; Q6LEU4; Q96QI8; Q9UQ17
• Molecular Weight: 25,619 Da
• NCBI Official Full Name: N-acetyltransferase 8
• NCBI Official Synonym Full Names: N-acetyltransferase 8 (GCN5-related, putative)
• NCBI Official Symbol: NAT8
• NCBI Official Synonym Symbols: GLA; CML1; CCNAT; Hcml1; ATase2; TSC501; TSC510
• NCBI Protein Information: N-acetyltransferase 8
• UniProt Protein Name: N-acetyltransferase 8
• Protein Family: N-acetyltransferase
• UniProt Gene Name: NAT8
• UniProt Synonym Gene Names: ATase2; CCNAT
• UniProt Entry Name: NAT8_HUMAN

NCBI Description

This gene, isolated using the differential display method to detect tissue-specific genes, is specifically expressed in kidney and liver. The encoded protein shows amino acid sequence similarity to N-acetyltransferases. A similar protein in Xenopus affects cell adhesion and gastrulation movements, and may be localized in the secretory pathway. A highly similar paralog is found in a cluster with this gene. [provided by RefSeq, Sep 2008]

Uniprot Description

NAT8: Plays a role in regulation of gastrulation. Belongs to the camello family.

Protein type: Membrane protein, integral; Cell adhesion; EC 2.3.1.80; Membrane protein, multi-pass; Acetyltransferase

Chromosomal Location of Human Ortholog: 2p13.2

Cellular Component: endoplasmic reticulum membrane; ER-Golgi intermediate compartment; ER-Golgi intermediate compartment membrane; integral to membrane

Molecular Function: cysteine-S-conjugate N-acetyltransferase activity; lysine N-acetyltransferase activity; protein binding

Biological Process: beta-amyloid metabolic process; cellular protein metabolic process; glutathione metabolic process; negative regulation of apoptosis; peptidyl-lysine N6-acetylation; response to drug