Rabbit NAA15 Polyclonal Antibody | anti-NAA15 antibody

NAA15 Polyclonal Antibody

Cat. Num. AAA3002198

• Gene Names: NAA15; Ga19; NATH; TBDN; MRD50; NARG1; NAT1P; TBDN100
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: NAA15; Polyclonal Antibody; NAA15 Polyclonal Antibody; N-alpha-acetyltransferase 15; NatA auxiliary subunit; Gastric cancer antigen Ga19; N-terminal acetyltransferase; NMDA receptor-regulated protein 1; Protein tubedown-1; Tbdn100; GA19; NARG1; NATH; TBDN100; anti-NAA15 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: NARG1 polyclonal antibody detects endogenous levels of NARG1 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 866

• Applicable Applications for anti-NAA15 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: Synthetic peptide, corresponding Human NARG1.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of NARG1 polyclonal antibody at 1:500 dilutionLane1:The Testis tissue lysate of Rat (40ug) Lane2:The Eye tissue lysate of Mouse (40ug) Lane3:A375 whole cell lysate (40ug) Lane4:SCC-7 whole cell lysate (40ug))

Related Product Information for anti-NAA15 antibody

NARG1 (NMDA (N-methyl-delta-aspartate) receptor-regulated gene 1), also known as NATH (N-terminal acetyltransferase), TBDN100 (tubedown-1) or Ga19 (gastric cancer antigen Ga19), is a cytoplasmic protein that contains eight TPR repeats. NARG1 is expressed at high levels in dividing tissues such as bone marrow, testis and embryonal brain and it is overexpressed in papillary thyroid carcinomas. NARG1 interacts with ARD1 or ARD2 forming a complex that exhibits N-terminal (alpha) acetyltransferase activity. The complex interacts with ribosomal subunits functioning in cotranslational acetylation. During apoptosis, both NARG1 and ARD1 are cleaved by caspases which results in decreased acetyltransferase activity. Knockdown of NARG1 in HeLa cells leads to apoptosis, indicating that properly functioning NARG1 is essential for cell viability. In addition, this suggests NARG1 as a potential target in cancer therapy

NCBI and Uniprot Product Information

• NCBI GI #: 17149828
• NCBI GeneID: 80155
• NCBI Accession #: NP_476516.1
• NCBI GenBank Nucleotide #: NP_476516.1
• UniProt Accession #: Q9BXJ9
• Molecular Weight: ~ 101kDa
• NCBI Official Full Name: N-alpha-acetyltransferase 15, NatA auxiliary subunit
• NCBI Official Synonym Full Names: N-alpha-acetyltransferase 15, NatA auxiliary subunit
• NCBI Official Symbol: NAA15
• NCBI Official Synonym Symbols: Ga19; NATH; TBDN; MRD50; NARG1; NAT1P; TBDN100
• NCBI Protein Information: N-alpha-acetyltransferase 15, NatA auxiliary subunit
• UniProt Protein Name: N-alpha-acetyltransferase 15, NatA auxiliary subunit
• Protein Family: N-alpha-acetyltransferase
• UniProt Gene Name: NAA15
• UniProt Synonym Gene Names: GA19; NARG1; NATH; TBDN100
• UniProt Entry Name: NAA15_HUMAN

NCBI Description

N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes the auxillary subunit of the N-terminal acetyltransferase A (NatA) complex. [provided by RefSeq, Jan 2017]

Uniprot Description

NAA15: The NAA10-NAA15 complex displays alpha (N-terminal) acetyltransferase activity that may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Acetyltransferase

Chromosomal Location of Human Ortholog: 4q31.1

Cellular Component: transcription factor complex; membrane; cytoplasm; nucleus

Molecular Function: N-acetyltransferase activity; protein binding; acetyltransferase activity; ribosome binding

Biological Process: N-terminal protein amino acid acetylation; protein stabilization; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; angiogenesis; cell differentiation; negative regulation of apoptosis