Rabbit anti-Mouse MYPC3 Polyclonal Antibody | anti-MYPC3 antibody

Anti-MYPC3 Antibody

Cat. Num. AAA7607712

• Gene Names: MYBPC3; FHC; CMH4; CMD1MM; LVNC10; MYBP-C; cMyBP-C
• Reactivity: Mouse
• Applications: ELISA, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen affinity purified
• Synonyms: MYPC3; Polyclonal Antibody; Anti-MYPC3 Antibody; C-protein; cardiac muscle isoform; anti-MYPC3 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen affinity purified
• Form/Format: Liquid; PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
• Sequence Length: 1274

• Applicable Applications for anti-MYPC3 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1:50-1:500
• Immunogen: Myosin-binding Protein C, cardiac-type
• Preparation and Storage: Store at -20 degree C for 24 months. Avoid repeated freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded mouse heart tissue slide using MBS7607712 (MYPC3 antibody) at dilution of 1:200)

NCBI and Uniprot Product Information

• NCBI GI #: 148596957
• NCBI GeneID: 4607
• NCBI Accession #: NP_000247.2
• NCBI GenBank Nucleotide #: NP_000247.2
• UniProt Accession #: Q14896
• Molecular Weight: Observed MW: 141kDa
• NCBI Official Full Name: myosin-binding protein C, cardiac-type
• NCBI Official Synonym Full Names: myosin binding protein C3
• NCBI Official Symbol: MYBPC3
• NCBI Official Synonym Symbols: FHC; CMH4; CMD1MM; LVNC10; MYBP-C; cMyBP-C
• NCBI Protein Information: myosin-binding protein C, cardiac-type
• UniProt Protein Name: Myosin-binding protein C, cardiac-type
• UniProt Gene Name: MYBPC3
• UniProt Synonym Gene Names: Cardiac MyBP-C
• UniProt Entry Name: MYPC3_HUMAN

NCBI Description

MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]

Uniprot Description

MYBPC3: Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. Belongs to the immunoglobulin superfamily. MyBP family.

Protein type: Myosin-binding

Chromosomal Location of Human Ortholog: 11p11.2

Cellular Component: sarcomere; striated muscle thick filament; cytosol; A band

Molecular Function: identical protein binding; ATPase activator activity; myosin binding; structural constituent of muscle; metal ion binding; titin binding; actin binding; myosin heavy chain binding

Biological Process: heart morphogenesis; regulation of heart rate; positive regulation of ATPase activity; regulation of muscle filament sliding; regulation of striated muscle contraction; ventricular cardiac muscle morphogenesis; sarcomere organization; cell adhesion; myosin filament assembly; muscle filament sliding; cardiac muscle contraction

Disease: Left Ventricular Noncompaction 10; Cardiomyopathy, Familial Hypertrophic, 4