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Western Blot (WB) (Western blot analysis of MYOZ1 Antibody (Center) in MDA-MB231 cell line lysates (35ug/lane).MYOZ1 (arrow) was detected using the purified Pab.)

Rabbit anti-Human, Mouse MYOZ1 Polyclonal Antibody | anti-MYOZ1 antibody

MYOZ1, ID (MYOZ1, MYOZ, Myozenin-1, Calsarcin-2, Filamin-, actinin-and telethonin-binding protein, Protein FATZ) (APC)

Gene Names
MYOZ1; CS-2; FATZ; MYOZ
Reactivity
Human, Mouse
Applications
Flow Cytometry, Functional Assay, Immunohistochemistry, Western Blot
Purity
Purified by Protein A Affinity Chromatography.
Synonyms
MYOZ1; Polyclonal Antibody; ID (MYOZ1; MYOZ; Myozenin-1; Calsarcin-2; Filamin-; actinin-and telethonin-binding protein; Protein FATZ) (APC); Protein FATZ; anti-MYOZ1 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Purified by Protein A Affinity Chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).
Applicable Applications for anti-MYOZ1 antibody
Flow Cytometry (FC/FACS), FLISA, Immunohistochemistry (IHC), Western Blot (WB)
Application Notes
FC/FACS: 1:10-50
FLISA: 1:1,000
IHC: 1:50-100
WB: 1:100-500
Applications are based on unconjugated antibody.
Immunogen
MYOZ1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 48-78 amino acids from the Central region of human MYOZ1.
Conjugate
APC
Note
Preservative Free
Special Handling
Light sensitive
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western blot analysis of MYOZ1 Antibody (Center) in MDA-MB231 cell line lysates (35ug/lane).MYOZ1 (arrow) was detected using the purified Pab.)

Western Blot (WB) (Western blot analysis of MYOZ1 Antibody (Center) in MDA-MB231 cell line lysates (35ug/lane).MYOZ1 (arrow) was detected using the purified Pab.)

Immunohistochemistry (IHC)

(MYOZ1 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded mouse heart tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the MYOZ1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)

Immunohistochemistry (IHC) (MYOZ1 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded mouse heart tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the MYOZ1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)

Flow Cytometry (FC/FACS)

(MYOZ1 Antibody (Center) flow cytometric analysis of MDA-MB231 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)

Flow Cytometry (FC/FACS) (MYOZ1 Antibody (Center) flow cytometric analysis of MDA-MB231 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Related Product Information for anti-MYOZ1 antibody
Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. This protein plays an important role in the modulation of calcineurin signaling, may play a role in myofibrillogenesis.
Product Categories/Family for anti-MYOZ1 antibody
References
Aurino, S., et al. Acta Myol 27, 90-97 (2008). Posch, M.G., et al. Mol. Genet. Metab. 91(2):207-208(2007). Arola, A.M., et al. Mol. Genet. Metab. 90(4):435-440(2007).

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
299
NCBI Official Full Name
Myozenin-1
NCBI Official Synonym Full Names
myozenin 1
NCBI Official Symbol
MYOZ1
NCBI Official Synonym Symbols
CS-2; FATZ; MYOZ
NCBI Protein Information
myozenin-1; MYOZ1; calsarcin-2; filamin-, actinin- and telethonin-binding protein
UniProt Protein Name
Myozenin-1
Protein Family
UniProt Gene Name
MYOZ1
UniProt Entry Name
MYOZ1_HUMAN

NCBI Description

The protein encoded by this gene is primarily expressed in the skeletal muscle, and belongs to the myozenin family. Members of this family function as calcineurin-interacting proteins that help tether calcineurin to the sarcomere of cardiac and skeletal muscle. They play an important role in modulation of calcineurin signaling. [provided by RefSeq, Apr 2012]

Uniprot Description

MYOZ1: Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma- filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis. Belongs to the myozenin family.

Chromosomal Location of Human Ortholog: 10q22.1

Cellular Component: pseudopodium; nucleus; actin cytoskeleton

Molecular Function: protein binding; FATZ binding

Biological Process: myofibril assembly

Research Articles on MYOZ1

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Product Notes

The MYOZ1 myoz1 (Catalog #AAA6323540) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MYOZ1, ID (MYOZ1, MYOZ, Myozenin-1, Calsarcin-2, Filamin-, actinin-and telethonin-binding protein, Protein FATZ) (APC) reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's MYOZ1 can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS), FLISA, Immunohistochemistry (IHC), Western Blot (WB). FC/FACS: 1:10-50 FLISA: 1:1,000 IHC: 1:50-100 WB: 1:100-500 Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the MYOZ1 myoz1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MYOZ1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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