Western Blot (WB)
(MYOT Antibody (Center) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the MYOT antibody detected the MYOT protein (arrow).)
Rabbit anti-Human MYOT Polyclonal Antibody | anti-MYOT antibody
MYOT Antibody (Center)
Western Blot (WB)
(MYOT Antibody (Center) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the MYOT antibody detected the MYOT protein (arrow).)
Western Blot (WB)
(MYOT Antibody (Center) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the MYOT antibody detected the MYOT protein (arrow).)
significant role in the stability of thin filaments during muscle
contraction. This protein binds F-actin, crosslinks actin
filaments, and prevents latrunculin A-induced filament disassembly.
Mutations in this gene have been associated with limb-girdle
muscular dystrophy and myofibrillar myopathies. Several
alternatively spliced transcript variants of this gene have been
described, but the full-length nature of some of these variants has
not been determined.
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Shalaby, S., et al. J. Neuropathol. Exp. Neurol. 68(6):701-707(2009)
Heikkinen, O., et al. J. Biomol. NMR 44(2):107-112(2009)
Claeys, K.G., et al. Acta Neuropathol. 117(3):293-307(2009)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a cystoskeletal protein which plays a significant role in the stability of thin filaments during muscle contraction. This protein binds F-actin, crosslinks actin filaments, and prevents latrunculin A-induced filament disassembly. Mutations in this gene have been associated with limb-girdle muscular dystrophy and myofibrillar myopathies. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[provided by RefSeq, Oct 2008]
Uniprot Description
MYOT: Component of a complex of multiple actin cross-linking proteins. Involved in the control of myofibril assembly and stability at the Z lines in muscle cells. Defects in MYOT are the cause of limb-girdle muscular dystrophy type 1A (LGMD1A). LGMD1A is an autosomal dominant degenerative myopathy with onset within a mean age of 28 years. LGMD1A is characterized by progressive skeletal muscle weakness of the hip and shoulder girdles, later progressing to include distal weakness, as well as a distinctive dysarthric pattern of speech. Affected muscle exhibits disorganization and streaming of the Z-line. Defects in MYOT are the cause of myopathy myofibrillar type 3 (MFM3). A neuromuscular disorder characterized by progressive skeletal muscle weakness greater distally than proximally, tight heel cords, hyporeflexia, cardiomyopathy and peripheral neuropathy in some patients. Affected muscle exhibits disorganization and streaming of the Z-line, presence of large hyaline structures, excessive accumulation of myotilin and other ectopically expressed proteins and prominent congophilic deposits. Defects in MYOT are the cause of spheroid body myopathy (SBM). SBM is an autosomal dominant form of myofibrillar myopathy (MFM), characterized by slowly progressing proximal muscle weakness and dysarthric nasal speech. There is no evidence of cardiomyopathy. Muscle biopsy shows spheroid bodies within the type I muscle fibers. Belongs to the myotilin/palladin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 5q31
Cellular Component: Z disc; sarcolemma; actin cytoskeleton
Molecular Function: protein binding; structural constituent of muscle; alpha-actinin binding; actin binding
Biological Process: muscle contraction
Disease: Myopathy, Spheroid Body; Myopathy, Myofibrillar, 3; Muscular Dystrophy, Limb-girdle, Type 1a
Research Articles on MYOT
Similar Products
Product Notes
The MYOT myot (Catalog #AAA9207572) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 127-155. The MYOT Antibody (Center) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's MYOT can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the MYOT myot for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MYOT, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
