Western Blot (WB)
(Western Blot analysis of MXD4 expression in transfected 293T cell line by MXD4 polyclonal antibody. Lane 1: MXD4 transfected lysate (22.99kD). Lane 2: Non-transfected lysate.)
Mouse anti-Human MXD4 Polyclonal Antibody | anti-MXD4 antibody
MXD4 (Max Dimerization Protein 4, Max Dimerizer 4, Max-interacting Transcriptional Repressor MAD4, Max-associated Protein 4, Class C Basic Helix-loop-helix Protein 12, bHLHc12, MAD4)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Western Blot (WB)
(Western Blot analysis of MXD4 expression in transfected 293T cell line by MXD4 polyclonal antibody. Lane 1: MXD4 transfected lysate (22.99kD). Lane 2: Non-transfected lysate.)
Western Blot (WB)
(Western Blot analysis of MXD4 expression in transfected 293T cell line by MXD4 polyclonal antibody. Lane 1: MXD4 transfected lysate (22.99kD). Lane 2: Non-transfected lysate.)
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the MAD gene family . The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues. [provided by RefSeq, Jul 2008]
Uniprot Description
Mad4: Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation.
Chromosomal Location of Human Ortholog: 4p16.3
Cellular Component: nucleus
Molecular Function: protein dimerization activity; protein binding; DNA binding; transcription corepressor activity
Biological Process: negative regulation of cell proliferation; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter
Research Articles on MXD4
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Product Notes
The MXD4 mxd4 (Catalog #AAA644282) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The MXD4 (Max Dimerization Protein 4, Max Dimerizer 4, Max-interacting Transcriptional Repressor MAD4, Max-associated Protein 4, Class C Basic Helix-loop-helix Protein 12, bHLHc12, MAD4) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's MXD4 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Suitable for use in Western Blot. Researchers should empirically determine the suitability of the MXD4 mxd4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MELNSLLILL EAAEYLERRD REAEHGYASV LPFDGDFARE KTKAAGLVRK APNNRSSHNE LEKHRRAKLR LYLEQLKQLV PLGPDSTRHT TLSLLKRAKV HIKKLEEQDR RALSIKEQLQ QEHRFLKRRL EQLSVQSVER VRTDSTGSAV STDDSEQEVD IEGMEFGPGE LDSVGSSSDA DDHYSLQSGT GGDSGFGPHC RRLGRPALS. It is sometimes possible for the material contained within the vial of "MXD4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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