Rabbit anti-Human MUC20 Polyclonal Antibody | anti-MUC20 antibody

MUC20 (Mucin 20, MUC-20, KIAA1359, Mucin-20, FLJ14408, KIAA1359, UNQ2782/PRO7170) (HRP)

Cat. Num. AAA6386142

• Gene Names: MUC20; MUC-20
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: MUC20; Polyclonal Antibody; MUC20 (Mucin 20; MUC-20; KIAA1359; Mucin-20; FLJ14408; UNQ2782/PRO7170) (HRP); anti-MUC20 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human MUC20.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).

• Applicable Applications for anti-MUC20 antibody: Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Full length human MUC20, aa1-122 (AAH44243.1).
• Immunogen Sequence: MGCLWGLALPLFFFCWEVGVSGSSAGPSTRRADTAMTTDDTEVPAMTLAPGHAALETQTLSAETSSRASTPAGPIPEAETRGAKRISPARETRSFTKTSPNFMVLIATSVETSAASGSPEGAGMTTVQTITGSDPEEAIFDTLCTDDSSEEAKTLTMDILTLAHTSTEAKGLSSESSASSDGPHPVITPSRASESSASSDGPHPVITPSRASESSASSDGPHPVITPSWSPGSDVTLLAEALVTVTNIEVINCSITEIETTTSSIPGASDIDLIPTEGVKASSTSDPPALPDSTEAKPHITEVTASAETLSTAGTTESAAPHATVGTPLPTNSATEREVTAPGATTLSGALVTVSRNPLEETSALSVETPSYVKVSGAAPVSIEAGSAVGKTTSFAGSSASSYSPSEAALKNFTPSETPTMDIATKGPFPTSRDPLPSVPPTTTNSSRGTNSTLAKITTSAKTTMKPPTATPTTARTRPTTDVSAGENGGFLLLRLSVASPEDLTDPRVAERLMQQLHRELHAHAPHFQVSLLRVRRG
• Conjugate: HRP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of MUC20 expression in transfected 293T cell line by MUC20 polyclonal antibody. Lane 1: MUC20 transfected lysate (55.2kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-MUC20 antibody

May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression.

Product Categories/Family for anti-MUC20 antibody

Antibodies; Mucin

NCBI and Uniprot Product Information

• NCBI GI #: 28422590
• NCBI GeneID: 200958
• Molecular Weight: 68,308 Da
• NCBI Official Full Name: Homo sapiens mucin 20, cell surface associated, mRNA
• NCBI Official Synonym Full Names: mucin 20, cell surface associated
• NCBI Official Symbol: MUC20
• NCBI Official Synonym Symbols: MUC-20
• NCBI Protein Information: mucin-20
• Protein Family: Mucin

NCBI Description

This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins secreted by many epithelial tissues to form an insoluble mucous barrier. The C-terminus of this family member associates with the multifunctional docking site of the MET proto-oncogene and suppresses activation of some downstream MET signaling cascades. The protein features a mucin tandem repeat domain that varies between two and six copies in most individuals. Multiple variants encoding different isoforms have been found for this gene. A related pseudogene, which is also located on chromosome 3, has been identified. [provided by RefSeq, Apr 2014]