Rabbit MTTP Polyclonal Antibody | anti-MTTP antibody

MTTP (Microsomal Triglyceride Transfer Protein Large Subunit, ABL, MTP) (Biotin)

Cat. Num. AAA6427653

• Gene Names: MTTP; ABL; MTP
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Western Blot
• Purity: Purified by affinity chromatography.
• Synonyms: MTTP; Polyclonal Antibody; MTTP (Microsomal Triglyceride Transfer Protein Large Subunit; ABL; MTP) (Biotin); anti-MTTP antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes MTTP. Species Crossreactivity: human, mouse, rat
• Purity/Purification: Purified by affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
• Concentration: ~1mg/ml (varies by lot)

• Applicable Applications for anti-MTTP antibody: Immunohistochemistry (IHC), Western Blot (WB)
• Application Notes: IHC: 1:50-1:200; WB: 1:500-1:2000; Applications are based on unconjugated antibody.
• Immunogen: Recombinant protein corresponding to human MTTP.
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western blot analysis of extracts of 293 cell lines, using MTTP antibody.)

Product Categories/Family for anti-MTTP antibody

Antibodies; Lipoproteins

NCBI and Uniprot Product Information

• NCBI GI #: 1709167
• NCBI GeneID: 4547
• UniProt Accession #: P55157; Q08AM4; Q6P5T3; A8K428
• Molecular Weight: 894
• NCBI Official Full Name: Microsomal triglyceride transfer protein large subunit
• NCBI Official Synonym Full Names: microsomal triglyceride transfer protein
• NCBI Official Symbol: MTTP
• NCBI Official Synonym Symbols: ABL; MTP
• NCBI Protein Information: microsomal triglyceride transfer protein large subunit; microsomal triglyceride transfer protein (large polypeptide, 88kDa)
• UniProt Protein Name: Microsomal triglyceride transfer protein large subunit
• Protein Family: Microsomal triglyceride transfer protein
• UniProt Gene Name: MTTP
• UniProt Synonym Gene Names: MTP
• UniProt Entry Name: MTP_HUMAN

NCBI Description

MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia. [provided by RefSeq, Jul 2008]

Uniprot Description

MTTP: Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B. Defects in MTTP are the cause of abetalipoproteinemia (ABL). ABL is an autosomal recessive disorder of lipoprotein metabolism. Affected individuals produce virtually no circulating apolipoprotein B-containing lipoproteins (chylomicrons, VLDL, LDL, lipoprotein(A)). Malabsorption of the antioxidant vitamin E occurs, leading to spinocerebellar and retinal degeneration.

Protein type: Endoplasmic reticulum

Chromosomal Location of Human Ortholog: 4q24

Cellular Component: endoplasmic reticulum lumen; receptor complex

Molecular Function: lipid transporter activity; lipid binding

Biological Process: lipoprotein metabolic process; lipid metabolic process; lipid transport

Disease: Abdominal Obesity-metabolic Syndrome 1; Abetalipoproteinemia