Rabbit anti-Human, Mouse MTSS1 Polyclonal Antibody | anti-MTSS1 antibody

MTSS1 Rabbit pAb

Cat. Num. AAA4758485

• Gene Names: MTSS1; MIM; MIMA; MIMB
• Reactivity: Human, Mouse
• Applications: ELISA, Immunohistochemistry
• Purity: Affinity purified
• Synonyms: MTSS1; Polyclonal Antibody; MTSS1 Rabbit pAb; metastasis suppressor 1; MIM; MIMA; MIMB; anti-MTSS1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Purity/Purification: Affinity purified
• Form/Format: pH7.4 PBS, 0.05% NaN3, 40% Glycerol

• Applicable Applications for anti-MTSS1 antibody: ELISA (EIA), Immunohistochemistry-Paraffin (IHC-P)
• Application Notes: ELISA: 1:1000-1:2000; IHC: 1:25-1:100
• Immunogen: Synthetic peptide of human MTSS1
• Conjugation: Unconjugated
• Modification: Unmodified
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Immunohistochemistry (IHC)

(The image is immunohistochemistry of paraffin-embedded Human brain tissue using 861929(MTSS1 Antibody) at dilution 1/20.(Original magnification: ×200))

Immunohistochemistry (IHC)

(The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using 861929(MTSS1 Antibody) at dilution 1/20. (Original magnification: ×200))

Related Product Information for anti-MTSS1 antibody

MTSS1 (metastasis suppressor 1), also known as MIM, MIMA or MIMB, is a 755 amino acid protein that contains one Actin-binding WH2 (Wiskott-Aldrich syndrome protein homology-2) domain and one IMD domain. Expressed in a variety of tissues including testis, thymus, prostate, spleen, colon, uterus and blood, MTSS1 is thought to bind to Actin and, via this binding, may affect the dynamics of the cytoskeleton. Through its association with the cytoskeleton, MTSS1 plays a role in controlling the progression and metastasis of carcinomas in various organ sites throughout the body and, when expressed at normal levels, functions as a tumor suppressor. Overexpression of MTSS1 results in the formation of abnormal actin structures, an event that may lead to tumorigenesis. Three isoforms of MTSS1 exist due to alternative splicing events.

Product Categories/Family for anti-MTSS1 antibody

Primary antibody

NCBI and Uniprot Product Information

• NCBI GI #: 144226234
• NCBI GeneID: 9788
• NCBI Accession #: NP_055566.3
• NCBI GenBank Nucleotide #: NM_014751.5
• UniProt Accession #: O43312; Q8TCA2; Q96RX2; J3KNK6
• Molecular Weight: 82,680 Da
• NCBI Official Full Name: metastasis suppressor protein 1 isoform 2
• NCBI Official Synonym Full Names: metastasis suppressor 1
• NCBI Official Symbol: MTSS1
• NCBI Official Synonym Symbols: MIM; MIMA; MIMB
• NCBI Protein Information: metastasis suppressor protein 1; metastasis suppressor YGL-1; missing in metastasis protein
• UniProt Protein Name: Metastasis suppressor protein 1
• Protein Family: MTSS1-like protein
• UniProt Gene Name: MTSS1
• UniProt Synonym Gene Names: KIAA0429; MIM
• UniProt Entry Name: MTSS1_HUMAN

Uniprot Description

MTSS1: an intracellular protein that binds to actin and cortactin, and possesses tumor suppressor activity. Binds to the cytoplasmic domain of receptor protein tyrosine phosphatase delta. Senses and induces curved membranous curvatures important for cellular polarization, mobilization and endocytosis. May be related to cancer progression or tumor metastasis in a variety of organ sites. Its expression is down-regulated by MiR-135a. Downregulated in prostate cancer. Expressed in many tissues, including spleen, thymus, prostate, testis, uterus, colon, and peripheral blood. Belongs to the MTSS1 family. Three isoforms of the human protein are produced by alternative splicing.

Protein type: Tumor suppressor; Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 8p22

Cellular Component: ruffle; adherens junction; endocytic vesicle; cytoplasm; actin cytoskeleton

Molecular Function: actin monomer binding; actin filament binding; identical protein binding; protein binding; receptor binding

Biological Process: plasma membrane organization and biogenesis; in utero embryonic development; actin filament polymerization; microspike biogenesis; positive regulation of actin filament bundle formation; cell motility; cell adhesion; actin cytoskeleton organization and biogenesis; bone mineralization; transmembrane receptor protein tyrosine kinase signaling pathway; negative regulation of epithelial cell proliferation