Rabbit anti-Human MTMR3 Polyclonal Antibody | anti-MTMR3 antibody

MTMR3 Antibody, HRP Conjugated

Cat. Num. AAA7133736

• Gene Names: MTMR3; ZFYVE10; FYVE-DSP1
• Reactivity: Human
• Applications: ELISA
• Purity: >95%, Protein G Purified
• Synonyms: MTMR3; Polyclonal Antibody; MTMR3 Antibody; HRP Conjugated; Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Phosphatidylinositol-3;5-bisphosphate 3-phosphatase) (EC 3.1.3.95) (Phosphatidylinositol-3-phosphate phosphatase) (EC 3.1.3.64) (Zinc finger FYVE domain-containing protein 10); KIAA0371 ZFYVE10; anti-MTMR3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%, Protein G Purified
• Form/Format: Liquid; Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

• Applicable Applications for anti-MTMR3 antibody: ELISA (EIA)
• Immunogen: Recombinant Human Myotubularin-related protein 3 protein (652-899AA)
• Immunogen Species: Human
• Conjugate: HRP
• Preparation and Storage: Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.

Product Categories/Family for anti-MTMR3 antibody

Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 23510389
• NCBI GeneID: 8897
• NCBI Accession #: NP_694691.1
• NCBI GenBank Nucleotide #: NM_153051.2
• UniProt Accession #: Q13615; Q9NYN5; Q9NYN6; Q9UDX6; Q9UEG3; A5PL26; A7MD32
• Molecular Weight: 133,619 Da
• NCBI Official Full Name: myotubularin-related protein 3 isoform b
• NCBI Official Synonym Full Names: myotubularin related protein 3
• NCBI Official Symbol: MTMR3
• NCBI Official Synonym Symbols: ZFYVE10; FYVE-DSP1
• NCBI Protein Information: myotubularin-related protein 3; zinc finger, FYVE domain containing 10; zinc finger FYVE domain-containing protein 10; FYVE domain-containing dual specificity protein phosphatase 1; FYVE (Fab1 YGLO23 Vsp27 EEA1 domain) dual-specificity protein phosphatase
• UniProt Protein Name: Myotubularin-related protein 3
• UniProt Gene Name: MTMR3
• UniProt Synonym Gene Names: KIAA0371; ZFYVE10; FYVE-DSP1
• UniProt Entry Name: MTMR3_HUMAN

NCBI Description

This gene encodes a member of the myotubularin dual specificity protein phosphatase gene family. The encoded protein is structurally similar to myotubularin but in addition contains a FYVE domain and an N-terminal PH-GRAM domain. The protein can self-associate and also form heteromers with another myotubularin related protein. The protein binds to phosphoinositide lipids through the PH-GRAM domain, and can hydrolyze phosphatidylinositol(3)-phosphate and phosphatidylinositol(3,5)-biphosphate in vitro. The encoded protein has been observed to have a perinuclear, possibly membrane-bound, distribution in cells, but it has also been found free in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

MTMR3: Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues. Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.3.95; Motility/polarity/chemotaxis; EC 3.1.3.48; EC 3.1.3.64; Protein phosphatase, dual-specificity

Chromosomal Location of Human Ortholog: 22q12.2

Cellular Component: nucleoplasm; extrinsic to membrane; membrane; cytoplasm; cytosol

Molecular Function: phosphatidylinositol-3-phosphatase activity; metal ion binding; protein tyrosine phosphatase activity; protein serine/threonine phosphatase activity

Biological Process: phospholipid metabolic process; phosphatidylinositol biosynthetic process; phosphoinositide dephosphorylation; protein amino acid dephosphorylation