Mouse anti-Human MTMR3 Polyclonal Antibody | anti-MTMR3 antibody

MTMR3 (Myotubularin-related Protein 3, FYVE Domain-containing Dual Specificity Protein Phosphatase 1, FYVE-DSP1, Zinc Finger FYVE Domain-containing Protein 10, KIAA0371, ZFYVE10, FLJ32333)

Cat. Num. AAA6005047

• Gene Names: MTMR3; ZFYVE10; FYVE-DSP1
• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: MTMR3; Polyclonal Antibody; MTMR3 (Myotubularin-related Protein 3; FYVE Domain-containing Dual Specificity Protein Phosphatase 1; FYVE-DSP1; Zinc Finger FYVE Domain-containing Protein 10; KIAA0371; ZFYVE10; FLJ32333); Anti -MTMR3 (Myotubularin-related Protein 3; anti-MTMR3 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human MTMR3.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2.
• Sequence: MDEETRHSLECIQANQIFPRKQLIREDENLQVPFLELHGESTEFVGRAEDAIIALSNYRLHIKFKESLVNVPLQLIESVECRDIFQLHLTCKDCKVIRCQFSTFEQCQEWLKRLNNAIRPPAKIEDLFSFAYHAWCMEVYASEKEQHGDLCRPGEHVTSRFKNEVERMGFDMNNAWRISNINEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPAVIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACASDSRSSGSKLSTRNTSRDFPNGGDLSDVEFDSSLSNASGAESLAIQPQKLLILDARSYAAAVANRAKGGGCECPEYYPNCEVVFMGMANIHSIRRSFQSLRLLCTQMPDPGNWLSALESTKWLHHLSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGHGENSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAKERGEKHTQERTCSVWSLLRAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLWSAVYLPCPSPTTPVDDSCAPYPAPGTSPDDPPLSRLPKTRSYDNLTTACDNTVPLASRRCSDPSLNEKWQEHRRSLELSSLAGPGEDPLSADSLGKPTRVPGGAELSVAAGVAEGQMENILQEATKEESGVEEPAHRAGIEIQEGKEDPLLEKESRRKTPEASAIGLHQDPELGDAALRSHLDMSWPLFSQGISEQQSGLSVLLSSLQVPPRGEDSLEVPVEQFRIEEIAEGREEAVLPIPVDAKVGYGTSQSCSLLPSQVPFETRGPNVDSSTDMLVEDKVKSVSGPQGHHRSCLVNSGKDRLPQTMEPSPSETSLVERPQVGSVVHRTSLGSTLSLTRSPCALPLAECKEGLVCNGAPETENRASEQPPGLSTLQMYPTPNGHCANGEAGRSKDSLSRQLSAMSCSSAHLHSRNLHHKWLHSHSGRPSATSSPDQPSRSHLDDDGMSVYTDTIQQRLRQIESGHQQEVETLKKQVQELKSRLESQYLTSSLHFNGDFGDEVTSIPDSESNLDQNCLSRCSTEIFSEASWEQVDKQDTEMTRWLPDHLAAHCYACDSAFWLASRKHHCRNCGNVFCSSCCNQKVPVPSQQLFEPSRVCKSCYSSLHPTSSSIDLELDKPIAATSN

• Applicable Applications for anti-MTMR3 antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.
• Immunogen: Full length human MTMR3, aa1-1198 (NP_066576.).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of MTMR3 expression in transfected 293T cell line by MTMR3 polyclonal antibody. Lane 1: MTMR3 transfected lysate (131.78kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-MTMR3 antibody

Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues.

Product Categories/Family for anti-MTMR3 antibody

Antibodies; Abs to Protein Phosphatases

NCBI and Uniprot Product Information

• NCBI GI #: 23510389
• NCBI GeneID: 8897
• NCBI Accession #: NP_694691.1
• NCBI GenBank Nucleotide #: NM_153051.2
• UniProt Accession #: Q13615; Q9NYN5; Q9NYN6; Q9UDX6; Q9UEG3; A5PL26; A7MD32
• Molecular Weight: 133,619 Da
• NCBI Official Full Name: myotubularin-related protein 3 isoform b
• NCBI Official Synonym Full Names: myotubularin related protein 3
• NCBI Official Symbol: MTMR3
• NCBI Official Synonym Symbols: ZFYVE10; FYVE-DSP1
• NCBI Protein Information: myotubularin-related protein 3; zinc finger, FYVE domain containing 10; zinc finger FYVE domain-containing protein 10; FYVE domain-containing dual specificity protein phosphatase 1; FYVE (Fab1 YGLO23 Vsp27 EEA1 domain) dual-specificity protein phosphatase
• UniProt Protein Name: Myotubularin-related protein 3
• UniProt Gene Name: MTMR3
• UniProt Synonym Gene Names: KIAA0371; ZFYVE10; FYVE-DSP1
• UniProt Entry Name: MTMR3_HUMAN

NCBI Description

This gene encodes a member of the myotubularin dual specificity protein phosphatase gene family. The encoded protein is structurally similar to myotubularin but in addition contains a FYVE domain and an N-terminal PH-GRAM domain. The protein can self-associate and also form heteromers with another myotubularin related protein. The protein binds to phosphoinositide lipids through the PH-GRAM domain, and can hydrolyze phosphatidylinositol(3)-phosphate and phosphatidylinositol(3,5)-biphosphate in vitro. The encoded protein has been observed to have a perinuclear, possibly membrane-bound, distribution in cells, but it has also been found free in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

MTMR3: Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues. Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; EC 3.1.3.48; EC 3.1.3.95; EC 3.1.3.64; Protein phosphatase, dual-specificity

Chromosomal Location of Human Ortholog: 22q12.2

Cellular Component: nucleoplasm; extrinsic to membrane; membrane; cytoplasm; cytosol

Molecular Function: phosphatidylinositol-3-phosphatase activity; metal ion binding; protein tyrosine phosphatase activity; protein serine/threonine phosphatase activity

Biological Process: phospholipid metabolic process; phosphatidylinositol biosynthetic process; phosphoinositide dephosphorylation; protein amino acid dephosphorylation