Western Blot (WB)
(HeLa cells were subjected to SDS PAGE followed by western blot with MBS7601642 (MTMR15 antibody) at dilution of 1:500)
Rabbit anti-Human MTMR15 Polyclonal Antibody | anti-MTMR15 antibody
MTMR15 Rabbit Polyclonal
Immunogen Affinity Purified
Immunogen Affinity Purified
Western Blot (WB)
(HeLa cells were subjected to SDS PAGE followed by western blot with MBS7601642 (MTMR15 antibody) at dilution of 1:500)
Western Blot (WB)
(HeLa cells were subjected to SDS PAGE followed by western blot with MBS7601642 (MTMR15 antibody) at dilution of 1:500)
NCBI and Uniprot Product Information
NCBI Description
This gene plays a role in DNA interstrand cross-link repair and encodes a protein with 5' flap endonuclease and 5'-3' exonuclease activity. Mutations in this gene cause karyomegalic interstitial nephritis. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Feb 2016]
Uniprot Description
FAN1: Nuclease required for maintenance of chromosomal stability. Plays a key role in DNA repair of DNA interstrand cross-links (ICL) by being recruited to sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL- induced DNA breaks by being required for efficient homologous recombination, possibly in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Has both endonuclease activity toward 5'-flaps and 5'-exonuclease activity: may act in concert with the 3'-flap- specific enzymes to unhook the ICL by cleaving the lagging-strand template. Belongs to the FAN1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.1.4.1; DNA repair, damage; Ubiquitin conjugating system; Deoxyribonuclease
Chromosomal Location of Human Ortholog: 15q13.2-q13.3
Cellular Component: cytoplasm; intercellular bridge; nucleoplasm; nucleus
Molecular Function: 5'-3' exonuclease activity; 5'-flap endonuclease activity; magnesium ion binding; phosphodiesterase I activity; protein binding; ubiquitin binding
Biological Process: DNA repair; double-strand break repair via homologous recombination; nucleotide-excision repair; nucleotide-excision repair, DNA incision
Disease: Interstitial Nephritis, Karyomegalic
Research Articles on MTMR15
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Product Notes
The MTMR15 fan1 (Catalog #AAA7601642) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MTMR15 Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's MTMR15 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Researchers should empirically determine the suitability of the MTMR15 fan1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MTMR15, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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