Related Product Information for anti-MTMR14 antibody
This gene encodes a myotubularin-related protein. The encoded protein is a phosphoinositide phosphatase that specifically dephosphorylates phosphatidylinositol 3,5-biphosphate and phosphatidylinositol 3-phosphate. Mutations in this gene are correlated with autosomal dominant centronuclear myopathy. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 18.
Product Categories/Family for anti-MTMR14 antibody
References
Gibbs, E.M., et al. Autophagy 6(6):819-820(2010). Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Vergne, I., et al. EMBO J. 28(15):2244-2258(2009). Tosch, V., et al. Hum. Mol. Genet. 15(21):3098-3106(2006).
Uniprot Description
MTMR14: Lipid phosphatase which efficiently dephosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2; inactive toward PtdIns4P, PtdIns(3,4)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P3. Expressed in various tissues, including heart, skeletal muscle, placenta, liver, lung, kidney and pancreas. Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Protein phosphatase, tyrosine (non-receptor); EC 3.1.3.-; Phosphatase, lipid
Chromosomal Location of Human Ortholog: 3p26
Cellular Component: ruffle; perinuclear region of cytoplasm; cytosol
Molecular Function: phosphatidylinositol-3-phosphatase activity; protein tyrosine phosphatase activity
Biological Process: phospholipid metabolic process; phosphatidylinositol biosynthetic process
Disease: Myopathy, Centronuclear, 1
Product Notes
The MTMR14 mtmr14 (Catalog #
AAA6322811) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MTMR14, NT (MTMR14, C3orf29, Myotubularin-related protein 14, HCV NS5A-transactivated protein 4 splice variant A-binding protein 1, hJumpy) (MaxLight 750) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's MTMR14 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), FLISA. WB: 1:100-500 FLISA: 1:1,000 Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the MTMR14 mtmr14 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
It is sometimes possible for the material contained within the vial of
"MTMR14, Polyclonal Antibody" to become dispersed throughout the inside of
the vial, particularly around the seal of said vial, during shipment and storage. We always
suggest centrifuging these vials
to consolidate all of the liquid away from the lid and to the bottom of the vial prior to
opening. Please be advised that
certain products may require dry ice for shipping and that, if this is the case, an
additional dry ice fee may also be
required.
Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are
absolutely not suitable for use in any
sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a
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industry standard. AAA Biotech
and its authorized distribution partners reserve the right to refuse to fulfill any order if
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purchaser may be intending to use a product outside of our accepted criteria.
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