Western Blot (WB)
(Western blot analysis of extracts of mouse liver tissue and NCL-H460 cells, using MTM1 antibody.)
Rabbit MTM1 Polyclonal Antibody | anti-MTM1 antibody
MTM1 (Myotubular Myopathy 1, Myotubularin 1, CG2, XLMTM, MTMX, Myotubularin) (HRP)
WB: 1:500-1:2000
Applications are based on unconjugated antibody.
Western Blot (WB)
(Western blot analysis of extracts of mouse liver tissue and NCL-H460 cells, using MTM1 antibody.)
Western Blot (WB)
(Western blot analysis of extracts of mouse liver tissue and NCL-H460 cells, using MTM1 antibody.)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Osteosarcoma using MTM1 antibody.)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Osteosarcoma using MTM1 antibody.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a dual-specificity phosphatase that acts on both phosphotyrosine and phosphoserine. It is required for muscle cell differentiation and mutations in this gene have been identified as being responsible for X-linked myotubular myopathy. [provided by RefSeq, Jul 2008]
Uniprot Description
MTM1: Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine- containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not for myogenesis. Defects in MTM1 are the cause of centronuclear myopathy X-linked (CNMX). A congenital muscle disorder characterized by progressive muscular. weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers. Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
Protein type: EC 3.1.3.95; Motility/polarity/chemotaxis; EC 3.1.3.64; Protein phosphatase, dual-specificity
Chromosomal Location of Human Ortholog: Xq28
Cellular Component: ruffle; I band; late endosome; cytoplasm; plasma membrane; cytosol; filopodium
Molecular Function: protein binding; phosphatidylinositol-3-phosphatase activity; intermediate filament binding; protein tyrosine phosphatase activity; phosphoprotein phosphatase activity; phosphoinositide binding
Biological Process: muscle maintenance; protein transport; phospholipid metabolic process; phosphatidylinositol biosynthetic process; intermediate filament organization; phosphoinositide dephosphorylation; endosome to lysosome transport; protein amino acid dephosphorylation; mitochondrion distribution
Disease: Myopathy, Centronuclear, X-linked
Research Articles on MTM1
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Product Notes
The MTM1 mtm1 (Catalog #AAA6427578) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MTM1 (Myotubular Myopathy 1, Myotubularin 1, CG2, XLMTM, MTMX, Myotubularin) (HRP) reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's MTM1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), Western Blot (WB). IHC: 1:50-1:200 WB: 1:500-1:2000 Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the MTM1 mtm1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MTM1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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